Mtus1 microtubule associated scaffold protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mtus1provided by RGD
Full Name: microtubule associated scaffold protein 1provided by RGD
Primary source: RGD:631381
See related: EnsemblRapid:ENSRNOG00000010748 AllianceGenome:RGD:631381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ATIP4; Mtsg1; Atip3b
Summary: Predicted to enable microtubule binding activity. Involved in cellular response to angiotensin. Predicted to be located in microtubule cytoskeleton and nucleolus. Predicted to be active in nucleus. Predicted to colocalize with cytoplasm. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 617.5), Adrenal (RPKM 314.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (57905991..58051466)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51202497..51347794)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54240892..54386131)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first report to identify that ATIP may have a similar role in other disease states characterised by excessive growth
Title: Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2.
Expression levels of isoformes ATIP3 and ATIP4 in rat tissues were examined. There was little similarity in the relative tissue distribution of the various ATIP isoforms in rat and human
Title: Gene sequencing and tissue expression of unknown isoforms of an angiotensin II type 2 receptor interacting protein, ATIP, in the rat.

Submit: New GeneRIF Correction

General gene information

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Markers

AI481402 (e-PCR)
- UniSTS:159757

BE115024 (e-PCR)
- UniSTS:248113

BE112380 (e-PCR)
- UniSTS:246087

RH144607 (e-PCR)
- UniSTS:233852

AV013190 (e-PCR)
- UniSTS:165577

RH141185 (e-PCR)
- UniSTS:223181

RH142940 (e-PCR)
- UniSTS:232187

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
colocalizes_with cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated tumor suppressor 1 homolog

Names: angiotensin-II type 2 receptor-interacting protein; growth factor inhibitor; microtubule associated tumor suppressor 1; mitochondrial tumor suppressor 1; transcription factor MTSG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395000.1 → NP_001381929.1 microtubule-associated tumor suppressor 1 homolog isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

B1A2U8

Related

ENSRNOP00000069962.1, ENSRNOT00000079006.3

Conserved Domains (1) summary

TIGR02168
Location:835 → 1154

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_178093.2 → NP_835194.2 microtubule-associated tumor suppressor 1 homolog isoform 2

See identical proteins and their annotated locations for NP_835194.2

Status: VALIDATED

Source sequence(s)

BC072537

UniProtKB/Swiss-Prot

Q6IMY1, Q6XUU5, Q80Z99

UniProtKB/TrEMBL

A6JPU4, I7GGY1

Related

ENSRNOP00000030995.2, ENSRNOT00000037685.7

Conserved Domains (1) summary

TIGR02168
Location:66 → 385

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

57905991..58051466

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253181.5 → XP_006253243.1 microtubule-associated tumor suppressor 1 homolog isoform X1

See identical proteins and their annotated locations for XP_006253243.1

UniProtKB/TrEMBL

B1A2U8

Conserved Domains (1) summary

TIGR02168
Location:835 → 1154

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_063275428.1 → XP_063131498.1 microtubule-associated tumor suppressor 1 homolog isoform X1

UniProtKB/TrEMBL

B1A2U8
XM_017600120.3 → XP_017455609.1 microtubule-associated tumor suppressor 1 homolog isoform X3

UniProtKB/TrEMBL

A0A8I5ZY91, I7GGY1

Related

ENSRNOP00000102205.1, ENSRNOT00000153250.1
XM_006253182.5 → XP_006253244.1 microtubule-associated tumor suppressor 1 homolog isoform X2

See identical proteins and their annotated locations for XP_006253244.1

UniProtKB/TrEMBL

D2XRB8

Related

ENSRNOP00000070944.1, ENSRNOT00000090266.3

Conserved Domains (2) summary

pfam09755
Location:193 → 460

DUF2046; Uncharacterized conserved protein H4 (DUF2046)

cl19219
Location:330 → 406

DUF342; Protein of unknown function (DUF342)
XM_017600121.3 → XP_017455610.1 microtubule-associated tumor suppressor 1 homolog isoform X4

UniProtKB/TrEMBL

I7GGY1
XM_017600122.3 → XP_017455611.1 microtubule-associated tumor suppressor 1 homolog isoform X5

UniProtKB/TrEMBL

A0A8L2QL23, I7GGY1
XM_039094527.2 → XP_038950455.1 microtubule-associated tumor suppressor 1 homolog isoform X6

Related

ENSRNOP00000084500.2, ENSRNOT00000102597.2

Conserved Domains (1) summary

TIGR02168
Location:14 → 291

SMC_prok_B; chromosome segregation protein SMC, common bacterial type