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    Aak1 AP2 associated kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500244, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aak1provided by RGD
    Official Full Name
    AP2 associated kinase 1provided by RGD
    Primary source
    RGD:1305520
    See related
    EnsemblRapid:ENSRNOG00000018317 AllianceGenome:RGD:1305520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563580
    Summary
    Enables AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in presynaptic endocytosis and regulation of clathrin-dependent endocytosis. Located in cell leading edge and terminal bouton. Part of clathrin complex. Is active in calyx of Held. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 315.7), Adrenal (RPKM 93.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Aak1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120845012..121009170)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119300128..119451834)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118653851..118806796)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene annexin A4 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene uncharacterized LOC134486606 Neighboring gene uncharacterized LOC134486605 Neighboring gene ribosomal protein L22, pseudogene 2 Neighboring gene uncharacterized LOC134486608 Neighboring gene uncharacterized LOC120102328 Neighboring gene NFU1 iron-sulfur cluster scaffold Neighboring gene glutamine fructose-6-phosphate transaminase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables AP-2 adaptor complex binding  
    enables AP-2 adaptor complex binding PubMed 
    enables AP-2 adaptor complex binding  
    enables AP-2 adaptor complex binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Notch binding  
    enables Notch binding  
    enables Notch binding  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in presynaptic endocytosis PubMed 
    involved_in presynaptic endocytosis PubMed 
    involved_in presynaptic endocytosis  
    involved_in protein phosphorylation  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of clathrin-dependent endocytosis  
    involved_in regulation of clathrin-dependent endocytosis PubMed 
    involved_in regulation of clathrin-dependent endocytosis  
    involved_in regulation of clathrin-dependent endocytosis  
    involved_in regulation of protein localization  
    involved_in regulation of protein localization  
    involved_in regulation of protein localization  
    Component Evidence Code Pubs
    is_active_in calyx of Held PubMed 
    is_active_in calyx of Held PubMed 
    located_in cell leading edge PubMed 
    part_of clathrin complex PubMed 
    located_in clathrin-coated pit  
    located_in clathrin-coated vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynapse  
    is_active_in presynapse PubMed 
    located_in terminal bouton PubMed 

    General protein information

    Preferred Names
    AP2-associated protein kinase 1
    Names
    adaptor-associated kinase 1
    NP_001166921.1
    XP_006236895.1
    XP_006236896.1
    XP_017448306.1
    XP_017448307.1
    XP_017448308.1
    XP_017448309.1
    XP_017448310.1
    XP_017448311.1
    XP_038964087.1
    XP_038964088.1
    XP_038964089.1
    XP_038964090.1
    XP_063142600.1
    XP_063142601.1
    XP_063142602.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173450.1NP_001166921.1  AP2-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001166921.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P0C1X8
      UniProtKB/TrEMBL
      F1LRI7
      Related
      ENSRNOP00000044665.4, ENSRNOT00000043082.6
      Conserved Domains (2) summary
      smart00220
      Location:47307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      120845012..121009170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592818.3XP_017448307.1  AP2-associated protein kinase 1 isoform X1

    2. XM_017592822.3XP_017448311.1  AP2-associated protein kinase 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A256
      Related
      ENSRNOP00000084865.1, ENSRNOT00000118607.2
    3. XM_006236833.5XP_006236895.1  AP2-associated protein kinase 1 isoform X12

      See identical proteins and their annotated locations for XP_006236895.1

      UniProtKB/Swiss-Prot
      P0C1X8
      UniProtKB/TrEMBL
      F1LRI7
      Conserved Domains (2) summary
      smart00220
      Location:47307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    4. XM_017592817.3XP_017448306.1  AP2-associated protein kinase 1 isoform X1

    5. XM_017592820.3XP_017448309.1  AP2-associated protein kinase 1 isoform X4

      Related
      ENSRNOP00000078415.2, ENSRNOT00000104791.2
    6. XM_039108160.2XP_038964088.1  AP2-associated protein kinase 1 isoform X5

      Conserved Domains (3) summary
      cd14037
      Location:42316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam05109
      Location:320423
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15282
      Location:9821193
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
    7. XM_039108159.2XP_038964087.1  AP2-associated protein kinase 1 isoform X3

      Conserved Domains (3) summary
      cd14037
      Location:42316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam05109
      Location:320423
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15282
      Location:10581269
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
    8. XM_039108161.2XP_038964089.1  AP2-associated protein kinase 1 isoform X7

      Conserved Domains (3) summary
      cd14037
      Location:42316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam05109
      Location:320423
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15282
      Location:9501161
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
    9. XM_017592819.3XP_017448308.1  AP2-associated protein kinase 1 isoform X2

      Related
      ENSRNOP00000088529.2, ENSRNOT00000102896.2
    10. XM_063286530.1XP_063142600.1  AP2-associated protein kinase 1 isoform X6

    11. XM_017592821.3XP_017448310.1  AP2-associated protein kinase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6ALS6
      Related
      ENSRNOP00000094963.1, ENSRNOT00000096717.2
    12. XM_063286531.1XP_063142601.1  AP2-associated protein kinase 1 isoform X9

    13. XM_039108162.2XP_038964090.1  AP2-associated protein kinase 1 isoform X11

      Conserved Domains (3) summary
      cd14037
      Location:42316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam05109
      Location:320423
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15282
      Location:9151126
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
    14. XM_063286532.1XP_063142602.1  AP2-associated protein kinase 1 isoform X14

      UniProtKB/Swiss-Prot
      P0C1X8
    15. XM_006236834.5XP_006236896.1  AP2-associated protein kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      P0C1X8
      Conserved Domains (2) summary
      smart00220
      Location:47307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
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