Emx2 empty spiracles homeobox 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Emx2provided by RGD
Official Full Name: empty spiracles homeobox 2provided by RGD
Primary source: RGD:1564797
See related: EnsemblRapid:ENSRNOG00000009482 AllianceGenome:RGD:1564797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564797
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in nervous system development; regulation of transcription by RNA polymerase II; and stereocilium bundle organization. Predicted to act upstream of or within several processes, including forebrain development; neuron migration; and ureter morphogenesis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to human EMX2 (empty spiracles homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 78.6), Uterus (RPKM 43.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (268612663..268619671)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (258626584..258633594)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (280633938..280640946)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:164907

Emx2 (e-PCR), detects polymorphism
- UniSTS:234046

Emx2 (e-PCR), detects polymorphism
- UniSTS:238160

Emx2 (e-PCR), detects polymorphism
- UniSTS:226152

Emx2 (e-PCR), detects polymorphism
- UniSTS:547216

D1Mit14 (e-PCR), detects polymorphism
- UniSTS:118503

Emx2 (e-PCR), detects polymorphism
- UniSTS:530684

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex regionalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in stereocilium bundle organization	IEA Inferred from Electronic Annotation more info
involved_in stereocilium bundle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureter morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: homeobox protein EMX2

Names: empty spiracles homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.