Ppa2 inorganic pyrophosphatase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppa2provided by RGD
Official Full Name: inorganic pyrophosphatase 2provided by RGD
Primary source: RGD:1307965
See related: EnsemblRapid:ENSRNOG00000012091 AllianceGenome:RGD:1307965
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307965
Summary: Predicted to enable inorganic diphosphate phosphatase activity and protein serine/threonine phosphatase activity. Predicted to be involved in diphosphate metabolic process; phosphate-containing compound metabolic process; and regulation of mitochondrial membrane potential. Predicted to be active in mitochondrion and synapse. Orthologous to human PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 195.7), Heart (RPKM 116.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (224472738..224552101)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (221800791..221878079)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (238528978..238606903)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inorganic diphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphate-containing compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inorganic pyrophosphatase 2, mitochondrial

Names: pyrophosphatase (inorganic) 2

NP_001129343.1

EC 3.6.1.1

XP_006233389.1

EC 3.6.1.1

XP_038958390.1

EC 3.6.1.1

XP_063138033.1

EC 3.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135871.1 → NP_001129343.1 inorganic pyrophosphatase 2, mitochondrial

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HVU8

Conserved Domains (1) summary

cl00217
Location:23 → 284

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

224472738..224552101

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233327.5 → XP_006233389.1 inorganic pyrophosphatase 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A6HVU8, D4A830

Related

ENSRNOP00000016195.6, ENSRNOT00000016195.7

Conserved Domains (1) summary

cl00217
Location:23 → 284

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
XM_039102462.2 → XP_038958390.1 inorganic pyrophosphatase 2, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I5ZZ13

Conserved Domains (1) summary

cl00217
Location:1 → 196

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
XM_063281963.1 → XP_063138033.1 inorganic pyrophosphatase 2, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I5ZZ13