Ncr3 natural cytotoxicity triggering receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ncr3provided by RGD
Official Full Name: natural cytotoxicity triggering receptor 3provided by RGD
Primary source: RGD:727881
See related: AllianceGenome:RGD:727881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 1C7; Nkp30
Summary: Predicted to enable identical protein binding activity and immune receptor activity. Predicted to be involved in NK T cell activation; natural killer cell activation; and positive regulation of immune response. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in malaria. Orthologous to human NCR3 (natural cytotoxicity triggering receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 19.6), Testes (RPKM 16.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 20p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3642912..3648425, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3637242..3643748, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5170169..5175773)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Natural killer (NK) cell-activating receptor NKp30 plays dual activating roles while interacting with hepatoma cell line NK-McA in vitro by mediating cytokine production and cytotoxicity.
Title: Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.
NKp30 is indeed expressed in rodents and is a functional stimulatory receptor in a subset of rat natural killer cells
Title: NKp30 is a functional activation receptor on a subset of rat natural killer cells.
RNKp30 is a glycosylated surface NK cell receptor with limited polymorphism. This putative activation receptor is expressed in liver allografts and may participate in the innate immune response after transplantation.
Title: Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts.
cDNA from the rat 1C7 gene encodes a protein of 192 AA residues containing a single IgV-set domain in the extracellular region & a positively charged residue in the transmembrane region. 1C7 may be an NK-activating receptor. [1C7]
Title: Molecular characterization of the novel rat NK receptor 1C7.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables immune receptor activity	IEA Inferred from Electronic Annotation more info
enables immune receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NK T cell activation	IEA Inferred from Electronic Annotation more info
involved_in NK T cell activation	ISO Inferred from Sequence Orthology more info
involved_in immune response-activating cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-activating cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response-activating cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response-activating cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in natural killer cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: natural cytotoxicity triggering receptor 3

Names: NK receptor 1c7; NK-p30; natural killer cell p30-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181822.2 → NP_861543.2 natural cytotoxicity triggering receptor 3 precursor

See identical proteins and their annotated locations for NP_861543.2

Status: VALIDATED

Source sequence(s)

BX883046

UniProtKB/Swiss-Prot

Q80WM8, Q8CFD9, Q8CG11

UniProtKB/TrEMBL

A6KTW4, R9PXR3

Conserved Domains (2) summary

smart00410
Location:27 → 130

IG_like; Immunoglobulin like

pfam07686
Location:26 → 130

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3642912..3648425 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601573.3 → XP_017457062.1 natural cytotoxicity triggering receptor 3 isoform X2
XM_006256054.5 → XP_006256116.3 natural cytotoxicity triggering receptor 3 isoform X1

Conserved Domains (2) summary

cd00096
Location:21 → 26

Ig; Ig strand A [structural motif]

cl11960
Location:21 → 132

Ig; Immunoglobulin domain