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    Sf3b1 splicing factor 3b, subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84486, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sf3b1provided by RGD
    Official Full Name
    splicing factor 3b, subunit 1provided by RGD
    Primary source
    RGD:620148
    See related
    EnsemblRapid:ENSRNOG00000013516 AllianceGenome:RGD:620148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sap155
    Summary
    Predicted to enable chromatin binding activity; mRNA binding activity; and splicing factor binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase III and spliceosomal complex assembly. Predicted to act upstream of or within anterior/posterior pattern specification; blastocyst formation; and mRNA splicing, via spliceosome. Predicted to be located in chromatin; nuclear matrix; and nuclear speck. Predicted to be part of nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Orthologous to human SF3B1 (splicing factor 3b subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 798.0), Spleen (RPKM 680.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sf3b1 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (63986829..64026723, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (56492403..56532300, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (61594620..61634510, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 258 B Neighboring gene ribosomal protein L11, pseudogene 6 Neighboring gene coenzyme Q10B Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene heat shock protein family E (Hsp10) member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables chromatin binding  
    enables mRNA binding  
    enables splicing factor binding  
    Component Evidence Code Pubs
    part_of B-WICH complex  
    part_of U11/U12 snRNP  
    part_of U12-type spliceosomal complex  
    part_of U12-type spliceosomal complex  
    part_of U2 snRNP  
    part_of U2 snRNP  
    part_of U2-type precatalytic spliceosome  
    part_of U2-type prespliceosome  
    part_of U2-type spliceosomal complex  
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    located_in chromatin  
    located_in nuclear matrix  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleus  
    part_of small nuclear ribonucleoprotein complex  

    General protein information

    Preferred Names
    splicing factor 3B subunit 1
    Names
    splicing factor 3b, subunit 1, 155kD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053426.1NP_445878.1  splicing factor 3B subunit 1

      See identical proteins and their annotated locations for NP_445878.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AP19, A6IP03, G3V7T6
      Related
      ENSRNOP00000019126.4, ENSRNOT00000019126.7
      Conserved Domains (4) summary
      smart01104
      Location:241382
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5181
      Location:4461304
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      sd00044
      Location:850874
      HEAT; HEAT repeat [structural motif]
      pfam08920
      Location:332442
      SF3b1; Splicing factor 3B subunit 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      63986829..64026723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596654.2XP_017452143.1  splicing factor 3B subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP19
      Conserved Domains (4) summary
      smart01104
      Location:95236
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5181
      Location:3001158
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      sd00044
      Location:704728
      HEAT; HEAT repeat [structural motif]
      pfam08920
      Location:186296
      SF3b1; Splicing factor 3B subunit 1
    2. XM_063267778.1XP_063123848.1  splicing factor 3B subunit 1 isoform X2

      UniProtKB/TrEMBL
      A6IP04
    3. XM_063267777.1XP_063123847.1  splicing factor 3B subunit 1 isoform X2

      UniProtKB/TrEMBL
      A6IP04
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