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    Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajb9provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B9provided by RGD
    Primary source
    RGD:3070
    See related
    EnsemblRapid:ENSRNOG00000004006 AllianceGenome:RGD:3070
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mdg1; ERdj4
    Summary
    Predicted to enable Hsp70 protein binding activity and misfolded protein binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of IRE1-mediated unfolded protein response; and positive regulation of immunoglobulin production. Located in cytoplasm and nucleolus. Orthologous to human DNAJB9 (DnaJ heat shock protein family (Hsp40) member B9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 279.8), Heart (RPKM 260.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajb9 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (66997842..67007371, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61270385..61276795, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (64165913..64170122, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479371 Neighboring gene uncharacterized LOC134479372 Neighboring gene uncharacterized LOC120103526 Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 4 Neighboring gene patatin-like phospholipase domain containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The BiP cochaperone ERdj4 is required for B cell development and function. Fritz JM, et al. PLoS One, 2014. PMID 25222125, Free PMC Article
    2. High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells. Berger BJ, et al. Exp Cell Res, 2003 Oct 15. PMID 14516790
    3. Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis. Pröls F, et al. Exp Cell Res, 2001 Sep 10. PMID 11525638
    4. ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery. Lai CW, et al. J Biol Chem, 2012 Mar 9. PMID 22267725, Free PMC Article
    5. Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. Shen Y, et al. J Biol Chem, 2002 May 3. PMID 11836248

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of IRE1-mediated unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of immunoglobulin production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 9
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 9
    ER-resident protein ERdj4
    dnaJ homolog, subfamily b, member 9
    endoplasmic reticulum DNA J domain-containing protein 4
    mdg-1
    microvascular endothelial differentiation gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012699.3 → NP_036831.2  dnaJ homolog subfamily B member 9 precursor

      See identical proteins and their annotated locations for NP_036831.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P97554
      UniProtKB/TrEMBL
      A6HBE3
      Related
      ENSRNOP00000005363.3, ENSRNOT00000005363.7
      Conserved Domains (1) summary
      COG0484
      Location:23 → 135
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      66997842..67007371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111791.2 → XP_038967719.1  dnaJ homolog subfamily B member 9 isoform X1

      Related
      ENSRNOP00000099445.1, ENSRNOT00000160259.1
      Conserved Domains (1) summary
      COG0484
      Location:35 → 147
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97554.2 GenPept UniProtKB/Swiss-Prot:P97554

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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