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    Wdr41 WD repeat domain 41 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361879, updated on 27-Dec-2024

    Summary

    Official Symbol
    Wdr41provided by RGD
    Official Full Name
    WD repeat domain 41provided by RGD
    Primary source
    RGD:1306363
    See related
    EnsemblRapid:ENSRNOG00000025462 AllianceGenome:RGD:1306363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of autophagy. Predicted to be located in cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Orthologous to human WDR41 (WD repeat domain 41). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 78.6), Brain (RPKM 74.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Wdr41 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (27957453..28008573)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26222797..26273849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (24668108..24717280)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350223 Neighboring gene orthopedia homeobox Neighboring gene phosphodiesterase 8B Neighboring gene uncharacterized LOC134485577 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm  
    part_of guanyl-nucleotide exchange factor complex  

    General protein information

    Preferred Names
    WD repeat-containing protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395597.2NP_001382526.1  WD repeat-containing protein 41 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZYE1, B2RYI7
      Related
      ENSRNOP00000061347.3, ENSRNOT00000067022.6
      Conserved Domains (2) summary
      sd00039
      Location:87133
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:38350
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001395716.1NP_001382645.1  WD repeat-containing protein 41 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZYE1, F7ETI3
      Related
      ENSRNOP00000031387.7, ENSRNOT00000036748.7
      Conserved Domains (2) summary
      sd00039
      Location:87132
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:38349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      27957453..28008573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102530.2XP_038958458.1  WD repeat-containing protein 41 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYE1
      Related
      ENSRNOP00000084562.2, ENSRNOT00000109022.2
      Conserved Domains (2) summary
      sd00039
      Location:76122
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:27339
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

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