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    Agtr2 angiotensin II receptor, type 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24182, updated on 9-Dec-2024

    Summary

    Official Symbol
    Agtr2provided by RGD
    Official Full Name
    angiotensin II receptor, type 2provided by RGD
    Primary source
    RGD:2072
    See related
    EnsemblRapid:ENSRNOG00000050006 AllianceGenome:RGD:2072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AT2R; AT2-R; AT<sub>2</sub>R
    Summary
    Enables angiotensin type II receptor activity. Involved in several processes, including cellular response to dexamethasone stimulus; positive regulation of branching involved in ureteric bud morphogenesis; and regulation of secretion. Located in perinuclear region of cytoplasm. Used to study chronic kidney disease; congenital diaphragmatic hernia; glomerulonephritis (multiple); hypertension (multiple); and meconium aspiration syndrome. Biomarker of several diseases, including asthma; congestive heart failure; glomerulosclerosis (multiple); hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 176.0), Uterus (RPKM 25.3) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Agtr2 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (116914320..116918504)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (112119876..112124060)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (119389480..119393845)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911253 Neighboring gene poly(rC) binding protein 2, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorbitol dehydrogenase, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  
    involved_in angiotensin-activated signaling pathway  
    acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure  
    acts_upstream_of_or_within brain renin-angiotensin system  
    involved_in cell growth involved in cardiac muscle cell development PubMed 
    involved_in cell surface receptor signaling pathway  
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cerebellar cortex development PubMed 
    involved_in dopamine biosynthetic process PubMed 
    involved_in exploration behavior  
    involved_in inflammatory response  
    acts_upstream_of_or_within inflammatory response  
    involved_in intracellular sodium ion homeostasis PubMed 
    involved_in kidney development PubMed 
    involved_in kidney morphogenesis PubMed 
    involved_in negative regulation of fibroblast proliferation PubMed 
    involved_in negative regulation of heart rate  
    involved_in negative regulation of icosanoid secretion PubMed 
    NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process  
    involved_in negative regulation of neurotrophin TRK receptor signaling pathway  
    involved_in negative regulation of norepinephrine secretion PubMed 
    acts_upstream_of neuron apoptotic process  
    involved_in neuron differentiation PubMed 
    involved_in nitric oxide-cGMP-mediated signaling  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of branching involved in ureteric bud morphogenesis PubMed 
    involved_in positive regulation of branching involved in ureteric bud morphogenesis  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cytokine production PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    involved_in positive regulation of metanephric glomerulus development  
    involved_in regulation of metanephros size  
    involved_in regulation of protein import into nucleus PubMed 
    involved_in regulation of systemic arterial blood pressure by circulatory renin-angiotensin  
    involved_in renin-angiotensin regulation of aldosterone production PubMed 
    involved_in vasodilation PubMed 
    involved_in vasodilation  
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    type-2 angiotensin II receptor
    Names
    AT2
    AT2 receptor
    angiotensin II type 2 receptor
    angiotensin receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012494.4NP_036626.1  type-2 angiotensin II receptor

      See identical proteins and their annotated locations for NP_036626.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P35351
      UniProtKB/TrEMBL
      B1WBL8
      Related
      ENSRNOP00000106067.1, ENSRNOT00000157598.1
      Conserved Domains (1) summary
      cd15191
      Location:45329
      7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      116914320..116918504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279775.1XP_063135845.1  type-2 angiotensin II receptor isoform X1

      UniProtKB/Swiss-Prot
      P35351
      UniProtKB/TrEMBL
      B1WBL8
      Related
      ENSRNOP00000109539.1, ENSRNOT00000127414.1
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