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    A4galt alpha 1,4-galactosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63888, updated on 27-Dec-2024

    Summary

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    Official Symbol
    A4galtprovided by RGD
    Official Full Name
    alpha 1,4-galactosyltransferaseprovided by RGD
    Primary source
    RGD:621583
    See related
    EnsemblRapid:ENSRNOG00000009736 AllianceGenome:RGD:621583
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gb3
    Summary
    Enables galactosyltransferase activity. Predicted to be involved in glycosphingolipid biosynthetic process. Predicted to act upstream of or within globoside biosynthetic process and plasma membrane organization. Predicted to be located in membrane. Orthologous to human A4GALT (alpha 1,4-galactosyltransferase (P1PK blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 68.9), Heart (RPKM 15.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See A4galt in Genome Data Viewer
    Location:
    7q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116248571..116272917, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114368525..114392872, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124085832..124110440, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 38 Neighboring gene cytochrome b5 reductase 3 Neighboring gene ARF GTPase activating protein 3 Neighboring gene protein kinase C and casein kinase substrate in neurons 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The P blood group system: biochemical, serological, and clinical aspects. Spitalnik PF, et al. Transfus Med Rev, 1995 Apr. PMID 7795329
    2. Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals. Keusch JJ, et al. J Biol Chem, 2000 Aug 18. PMID 10854428
    3. Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids. Kojima Y, et al. J Biol Chem, 2000 May 19. PMID 10748143
    4. Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype. Steffensen R, et al. J Biol Chem, 2000 Jun 2. PMID 10747952
    5. Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. Okuda T, et al. J Biol Chem, 2006 Apr 14. PMID 16476743

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lactosylceramide 4-alpha-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within globoside biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lactosylceramide 4-alpha-galactosyltransferase
    Names
    Gb3 synthase
    UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
    alpha 1,4-galactosyltransferase (P blood group)
    alpha-1,4-N-acetylglucosaminyltransferase
    alpha4Gal-T1
    globotriaosylceramide synthase
    NP_071576.1
    XP_006242179.1
    XP_006242180.1
    XP_017450570.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022240.2 → NP_071576.1  lactosylceramide 4-alpha-galactosyltransferase

      See identical proteins and their annotated locations for NP_071576.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097323
      UniProtKB/Swiss-Prot
      Q4QR98, Q9JI93
      UniProtKB/TrEMBL
      A6HT88
      Conserved Domains (2) summary
      pfam04488
      Location:98 → 221
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:234 → 356
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116248571..116272917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242117.5 → XP_006242179.1  lactosylceramide 4-alpha-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006242179.1

      UniProtKB/Swiss-Prot
      Q4QR98, Q9JI93
      UniProtKB/TrEMBL
      A6HT88
      Conserved Domains (2) summary
      pfam04488
      Location:98 → 221
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:234 → 356
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

    2. XM_006242118.5 → XP_006242180.1  lactosylceramide 4-alpha-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006242180.1

      UniProtKB/Swiss-Prot
      Q4QR98, Q9JI93
      UniProtKB/TrEMBL
      A6HT88
      Related
      ENSRNOP00000112147.1, ENSRNOT00000122895.1
      Conserved Domains (2) summary
      pfam04488
      Location:98 → 221
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:234 → 356
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

    3. XM_017595081.3 → XP_017450570.1  lactosylceramide 4-alpha-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q4QR98, Q9JI93
      UniProtKB/TrEMBL
      A6HT88
      Related
      ENSRNOP00000064362.1, ENSRNOT00000012914.7
      Conserved Domains (2) summary
      pfam04488
      Location:98 → 221
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:234 → 356
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI93.1 GenPept UniProtKB/Swiss-Prot:Q9JI93

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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