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    Syn1 synapsin I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syn1provided by RGD
    Official Full Name
    synapsin Iprovided by RGD
    Primary source
    RGD:3797
    See related
    EnsemblRapid:ENSRNOG00000010365 AllianceGenome:RGD:3797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium-dependent protein binding activity. Involved in neuron development and synapse organization. Located in dendrite; presynaptic active zone; and synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 151.4), Spleen (RPKM 21.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Syn1 in Genome Data Viewer
    Location:
    Xq11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3725745..3780940)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1172208..1227400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1321315..1379202)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ETS transcription factor ELK1 Neighboring gene complement factor properdin Neighboring gene 60S ribosomal protein L12-like Neighboring gene TIMP metallopeptidase inhibitor 1 Neighboring gene A-Raf proto-oncogene, serine/threonine kinase Neighboring gene uncharacterized LOC134484040 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ribosomal protein L22 like 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural lecithin promotes neural network complexity and activity. Latifi S, et al. Sci Rep, 2016 May 27. PMID 27228907, Free PMC Article
    2. Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study. Ma W, et al. Curr Alzheimer Res, 2023. PMID 38213171
    3. Increased activation of synapsin 1 and mitogen-activated protein kinases/extracellular signal-regulated kinase in the amygdala of maternal separation rats. Park HJ, et al. CNS Neurosci Ther, 2014 Feb. PMID 24279756, Free PMC Article
    4. Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina. VanGuilder HD, et al. Eur J Neurosci, 2008 Jul. PMID 18662330
    5. Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter. Matsuzaki Y, et al. J Neurosci Methods, 2014 Feb 15. PMID 24361760

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.
      Title: Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.
    2. The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.
      Title: The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.
    3. MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
      Title: MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
    4. The miR1345p/Foxp2/Syn1 axis was found to contribute to cognitive impairment in a chronic ischemiainduced early VD model, which may enable the development of new therapeutic strategies for the prevention and treatment of VD.
      Title: miR‑134‑5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model.
    5. Study shows that neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion.
      Title: Neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion.
    6. The synapsin 1 in the insular cortex as a part of pathophysiological process that determines predisposition of Krushinsky-Molodkina rats to audiogenic seizures.
      Title: The expression and distribution of seizure-related and synaptic proteins in the insular cortex of rats genetically prone to audiogenic seizures.
    7. SUMOylation of synapsin Ia (SynIa) at K687 is necessary for SynIa function. Replacement of endogenous SynIa with a non-SUMOylatable mutant decreases the size of the releasable vesicle pool and impairs stimulated SV exocytosis.
      Title: SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.
    8. Report behavioral testing-related changes in the expression of synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats.
      Title: Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats.
    9. Results suggest a mechanism of A2aR modulation of neurotransmitter release in cultured cells from medulla oblongata and suggest that protein kinase A mediates this modulation of neurotransmitter release via synapsin I phosphorylation
      Title: Protein kinase A mediates adenosine A2a receptor modulation of neurotransmitter release via synapsin I phosphorylation in cultured cells from medulla oblongata.
    10. rSynI(1.0)-minCMV drives robust and neuron-specific transgene expression throughout the CNS and is therefore useful for viral vector-mediated neuron-specific gene delivery and generation of neuron-specific transgenic animals.
      Title: Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal bouton HDA PubMed 

    General protein information

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    Preferred Names
    synapsin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110782.2 → NP_001104252.1  synapsin-1 isoform b

      See identical proteins and their annotated locations for NP_001104252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1, which results in a frame-shift, and a shorter isoform (b) with a distinct C-terminus compared to isoform a.
      Source sequence(s)
      BG378858, CO401107, FQ084192, JAXUCZ010000021, M27924
      UniProtKB/TrEMBL
      A6JZR0
      Related
      ENSRNOP00000106852.1, ENSRNOT00000154183.1
      Conserved Domains (3) summary
      pfam02078
      Location:115 → 212
      Synapsin; Synapsin, N-terminal domain
      pfam10581
      Location:1 → 27
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:214 → 416
      ATP-grasp_4; ATP-grasp domain

    2. NM_019133.2 → NP_062006.1  synapsin-1 isoform a

      See identical proteins and their annotated locations for NP_062006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      BG378858, CO401107, FQ084192, JAXUCZ010000021, M27812
      UniProtKB/Swiss-Prot
      P09951, Q9WUX7
      UniProtKB/TrEMBL
      A6JZQ9
      Related
      ENSRNOP00000014250.5, ENSRNOT00000014250.8
      Conserved Domains (3) summary
      pfam02078
      Location:115 → 212
      Synapsin; Synapsin, N-terminal domain
      pfam10581
      Location:1 → 27
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:214 → 416
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      3725745..3780940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09951.3 GenPept UniProtKB/Swiss-Prot:P09951

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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