Sncb synuclein, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sncbprovided by RGD
Official Full Name: synuclein, betaprovided by RGD
Primary source: RGD:70992
See related: EnsemblRapid:ENSRNOG00000018039 AllianceGenome:RGD:70992
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables alpha-tubulin binding activity and beta-tubulin binding activity. Predicted to be involved in chemical synaptic transmission; synapse organization; and synaptic vesicle endocytosis. Predicted to act upstream of or within dopamine metabolic process and negative regulation of neuron apoptotic process. Located in growth cone; neuronal cell body; and terminal bouton. Is active in presynaptic cytosol. Used to study uveitis. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 334.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9851825..9860143)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9846802..9855013)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10384472..10392776)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons.
Title: Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons.
T cells directed against the neuronal protein beta-synuclein specifically invade the grey matter and is accompanied by the presentation of multifaceted clinical disease; findings reveal a previously unrecognized role of beta-synuclein in provoking T-cell-mediated pathology of the central nervous system
Title: β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.
The aim of this study was to elucidate the age-dependent role of Sncb in brain microvascular endothelial cells.
Title: Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro.
beta-synuclein is a potential carboxyl-terminal Src kinase-homologous kinase substrate; tyrosine(127) in beta-synuclein is the preferential phosphorylation site.
Title: Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.
Studies characterized sites of GlcNAcylation on neuronal proteins tau, synucleins, and methyl CpG-binding protein 2.
Title: Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry.
The significant increase in alpha-synuclein mRNA after ammonia treatment was confirmed by quantitative RT-PCR, but no change was observed in alpha-synuclein protein levels.
Title: Possible implication of ciliary neurotrophic factor (CNTF) and beta-synuclein in the ammonia effect on cultured rat astroglial cells: a study using DNA and protein microarrays.
For beta-synuclein, levels increased significantly only in the cerebral cortex and only from 5 d to 1 mo of age.
Title: Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats.
Immunization with a peptide from beta-synuclein results in acute paralytic encephalomyelitis, and uveitis is adoptively transferred with a T cell line and clones specific for beta-synuclein, detected by western blot in myelin.
Title: Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sncb (e-PCR), detects polymorphism
- UniSTS:231355

AI145381 (e-PCR)
- UniSTS:245443

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cuprous ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cuprous ion binding	IEA Inferred from Electronic Annotation more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables transition metal ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in inclusion body	IEA Inferred from Electronic Annotation more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	HDA more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-synuclein

Names: PNP 14; phosphoneuroprotein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.