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    Igf1 insulin-like growth factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24482, updated on 4-Jan-2025

    Summary

    Official Symbol
    Igf1provided by RGD
    Official Full Name
    insulin-like growth factor 1provided by RGD
    Primary source
    RGD:2868
    See related
    EnsemblRapid:ENSRNOG00000004517 AllianceGenome:RGD:2868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IGF
    Summary
    Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); borna disease; congenital diaphragmatic hernia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 1821.5), Uterus (RPKM 212.9) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Igf1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24169608..24249446)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22282895..22361972)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28412123..28491815)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479589 Neighboring gene uncharacterized LOC134479654 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma, pseudogene 6 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor activity  
    enables growth factor activity  
    enables growth factor activity PubMed 
    enables hormone activity  
    enables hormone activity PubMed 
    enables hormone activity  
    enables hormone activity  
    enables insulin receptor binding  
    enables insulin receptor binding  
    enables insulin-like growth factor receptor binding  
    enables insulin-like growth factor receptor binding PubMed 
    enables insulin-like growth factor receptor binding  
    enables insulin-like growth factor receptor binding  
    enables integrin binding  
    enables integrin binding  
    enables protein serine/threonine kinase activator activity PubMed 
    enables receptor ligand activity  
    enables steroid binding PubMed 
    enables transmembrane receptor protein tyrosine kinase activator activity  
    Items 1 - 25 of 212
    Process Evidence Code Pubs
    involved_in activation of protein kinase B activity  
    acts_upstream_of androgen receptor signaling pathway  
    acts_upstream_of_or_within blood vessel remodeling  
    involved_in bone development PubMed 
    involved_in bone mineralization involved in bone maturation  
    involved_in bone mineralization involved in bone maturation  
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube  
    involved_in cardiac atrium development PubMed 
    involved_in cell activation  
    acts_upstream_of_or_within cell activation  
    acts_upstream_of_or_within cell development  
    involved_in cell population proliferation  
    acts_upstream_of cell population proliferation  
    involved_in cell population proliferation  
    involved_in cell surface receptor signaling pathway via STAT  
    involved_in cell surface receptor signaling pathway via STAT  
    involved_in cellular response to Thyroglobulin triiodothyronine PubMed 
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to electrical stimulus PubMed 
    involved_in cellular response to estradiol stimulus PubMed 
    acts_upstream_of_or_within cellular response to glucose stimulus  
    involved_in cellular response to insulin stimulus PubMed 
    acts_upstream_of_or_within cellular response to insulin-like growth factor stimulus  
    involved_in cellular response to nicotine PubMed 
    involved_in cellular response to progesterone stimulus PubMed 
    involved_in cellular response to zinc ion starvation PubMed 
    acts_upstream_of cerebellar granule cell precursor proliferation  
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process  
    involved_in circadian rhythm  
    involved_in cranial suture morphogenesis PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception PubMed 
    acts_upstream_of_or_within exocrine pancreas development  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in female pregnancy PubMed 
    acts_upstream_of_or_within glial cell differentiation  
    acts_upstream_of_or_within inner ear development  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway  
    acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    acts_upstream_of_or_within lung alveolus development  
    acts_upstream_of_or_within lung development  
    acts_upstream_of_or_within lung lobe morphogenesis  
    acts_upstream_of_or_within lung vasculature development  
    acts_upstream_of_or_within mammary gland development  
    involved_in memory PubMed 
    acts_upstream_of_or_within multicellular organism growth  
    involved_in muscle hypertrophy  
    involved_in muscle hypertrophy  
    involved_in myoblast differentiation  
    involved_in myoblast differentiation  
    involved_in myoblast proliferation  
    involved_in myoblast proliferation  
    involved_in myotube cell development  
    involved_in myotube cell development  
    acts_upstream_of_or_within myotube differentiation  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of amyloid-beta formation  
    acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of cholangiocyte apoptotic process PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of immune system process PubMed 
    involved_in negative regulation of interleukin-1 beta production  
    involved_in negative regulation of interleukin-1 beta production  
    involved_in negative regulation of muscle cell apoptotic process PubMed 
    involved_in negative regulation of neuroinflammatory response  
    involved_in negative regulation of neuroinflammatory response  
    involved_in negative regulation of oligodendrocyte apoptotic process PubMed 
    involved_in negative regulation of oocyte development  
    involved_in negative regulation of oocyte development  
    acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in negative regulation of smooth muscle cell apoptotic process PubMed 
    involved_in negative regulation of smooth muscle cell apoptotic process  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of vascular associated smooth muscle cell apoptotic process  
    involved_in negative regulation of vascular associated smooth muscle cell apoptotic process  
    acts_upstream_of_or_within nervous system development  
    involved_in osteoblast differentiation  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of activated T cell proliferation  
    involved_in positive regulation of activated T cell proliferation  
    involved_in positive regulation of blood vessel endothelial cell migration PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell growth involved in cardiac muscle cell development  
    involved_in positive regulation of cell growth involved in cardiac muscle cell development  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of fat cell differentiation PubMed 
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glial cell proliferation PubMed 
    involved_in positive regulation of glycogen biosynthetic process  
    involved_in positive regulation of glycogen biosynthetic process  
    involved_in positive regulation of glycogen biosynthetic process  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of glycoprotein biosynthetic process  
    involved_in positive regulation of glycoprotein biosynthetic process  
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway  
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway  
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of myelination  
    acts_upstream_of_or_within positive regulation of myoblast proliferation  
    involved_in positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein secretion  
    involved_in positive regulation of protein secretion  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of steroid hormone biosynthetic process PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of trophectodermal cell proliferation  
    involved_in positive regulation of trophectodermal cell proliferation  
    acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of vascular endothelial cell proliferation PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission  
    acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  
    acts_upstream_of_or_within prostate gland epithelium morphogenesis  
    acts_upstream_of_or_within prostate gland growth  
    acts_upstream_of_or_within prostate gland stromal morphogenesis  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in proteoglycan biosynthetic process  
    involved_in proteoglycan biosynthetic process  
    involved_in regulation of calcium ion transport PubMed 
    involved_in regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of establishment or maintenance of cell polarity  
    involved_in regulation of gene expression  
    acts_upstream_of_or_within regulation of nitric oxide biosynthetic process  
    acts_upstream_of_or_within regulation of protein metabolic process  
    acts_upstream_of_or_within regulation of protein phosphorylation  
    involved_in regulation of translation PubMed 
    involved_in response to activity PubMed 
    involved_in response to caffeine PubMed 
    involved_in response to epidermal growth factor PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to growth hormone PubMed 
    involved_in response to heat  
    involved_in response to heat  
    involved_in response to hypoxia PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to nicotine PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to starvation PubMed 
    involved_in response to steroid hormone PubMed 
    involved_in response to thyroid hormone PubMed 
    involved_in retinal cell apoptotic process PubMed 
    involved_in signal transduction  
    involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  
    involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  
    acts_upstream_of type B pancreatic cell proliferation  
    acts_upstream_of_or_within type I pneumocyte differentiation  
    acts_upstream_of_or_within type II pneumocyte differentiation  
    involved_in wound healing  
    involved_in wound healing  
    Items 1 - 25 of 212
    Component Evidence Code Pubs
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
    located_in exocytic vesicle  
    located_in exocytic vesicle  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in extracellular space  
    is_active_in glutamatergic synapse  
    part_of insulin-like growth factor ternary complex  
    part_of insulin-like growth factor ternary complex  
    located_in interstitial matrix PubMed 
    located_in neuronal cell body PubMed 
    is_active_in neuronal dense core vesicle lumen  
    located_in plasma membrane  
    located_in platelet alpha granule PubMed 
    located_in postsynapse  

    General protein information

    Preferred Names
    insulin-like growth factor 1; insulin-like growth factor I
    Names
    IGF-I
    Insulin-like growth factor I
    somatomedin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082477.2NP_001075946.2  insulin-like growth factor 1 isoform a preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (a) with a novel C-terminus, compared to isoform c. This isoform is also known as IIC.
      Source sequence(s)
      BC086374, CB761687, M15480, M17593
      UniProtKB/TrEMBL
      A0A0G2JX40
      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    2. NM_001082478.1NP_001075947.1  insulin-like growth factor 1 isoform c preproprotein

      See identical proteins and their annotated locations for NP_001075947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest variant and encodes isoform c. This isoform is also known as IB.
      Source sequence(s)
      BC086374, CB751206, CB761687, M15480
      UniProtKB/TrEMBL
      A6IFM0, A6IFM1, F8WFZ5
      Related
      ENSRNOP00000005995.5, ENSRNOT00000005995.7
      Conserved Domains (1) summary
      cd04368
      Location:49116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    3. NM_001082479.1NP_001075948.1  insulin-like growth factor 1 isoform d preproprotein

      See identical proteins and their annotated locations for NP_001075948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 3, resulting in a protein (isoform d) with a novel C-terminus, compared to isoform c. This isoform is also known as IA.
      Source sequence(s)
      BC086374, CB751206, CB761687
      UniProtKB/Swiss-Prot
      P08024, P08025
      UniProtKB/TrEMBL
      A6IFL5, Q5RK13
      Related
      ENSRNOP00000035899.6, ENSRNOT00000038780.8
      Conserved Domains (1) summary
      cd04368
      Location:49116
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    4. NM_178866.4NP_849197.3  insulin-like growth factor 1 isoform b preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences which include the absence of an alternate frame-shifting exon, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (b) with novel N- and C-termini, compared to isoform c. This isoform is also known as IIA.
      Source sequence(s)
      BC086374, CB761687
      UniProtKB/TrEMBL
      Q5RK13
      Related
      ENSRNOP00000110287.1, ENSRNOT00000130023.1
      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      24169608..24249446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262981.1XP_063119051.1  insulin-like growth factor I isoform X1

      UniProtKB/TrEMBL
      A6IFM0, A6IFM1, F8WFZ5
    2. XM_063262982.1XP_063119052.1  insulin-like growth factor I isoform X2

      UniProtKB/Swiss-Prot
      P08024, P08025
      UniProtKB/TrEMBL
      A6IFL5, Q5RK13
    3. XM_006241193.5XP_006241255.1  insulin-like growth factor I isoform X2

      See identical proteins and their annotated locations for XP_006241255.1

      UniProtKB/Swiss-Prot
      P08024, P08025
      UniProtKB/TrEMBL
      A6IFL5, Q5RK13
      Related
      ENSRNOP00000097781.2, ENSRNOT00000118307.2
      Conserved Domains (1) summary
      cd04368
      Location:49116
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    4. XM_006241191.4XP_006241253.1  insulin-like growth factor I isoform X1

      See identical proteins and their annotated locations for XP_006241253.1

      UniProtKB/TrEMBL
      A6IFM0, A6IFM1, F8WFZ5
      Conserved Domains (1) summary
      cd04368
      Location:49116
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    5. XM_006241194.5XP_006241256.1  insulin-like growth factor I isoform X3

      UniProtKB/TrEMBL
      Q5RK13
      Related
      ENSRNOP00000100217.1, ENSRNOT00000139084.1
      Conserved Domains (1) summary
      cd04368
      Location:2390
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
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