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    Mtx1 Metaxin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtx1provided by RGD
    Official Full Name
    Metaxin 1provided by RGD
    Primary source
    RGD:1559791
    See related
    EnsemblRapid:ENSRNOG00000042977 AllianceGenome:RGD:1559791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in lactation. Predicted to be located in mitochondrion. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX1 (metaxin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 105.4), Kidney (RPKM 93.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtx1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176913225..176919148, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174615460..174621383, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188522605..188528747, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550011 Neighboring gene glucosylceramidase beta 1 Neighboring gene transfer RNA valine (anticodon AAC) 42 Neighboring gene thrombospondin 3 Neighboring gene microRNA 92b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids. Gilchrist SE, et al. Fundam Clin Pharmacol, 2010 Apr. PMID 19702690
    2. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
    3. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in lactation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metaxin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100667.2 → NP_001094137.1  metaxin-1 isoform 2

      See identical proteins and their annotated locations for NP_001094137.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      B0BN02, E9PTW6, Q4KLN2
      Related
      ENSRNOP00000061267.2, ENSRNOT00000064715.5
      Conserved Domains (2) summary
      cd03212
      Location:223 → 356
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      cd03078
      Location:150 → 222
      GST_N_Metaxin1_like; GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the ...

    2. NM_001399239.1 → NP_001386168.1  metaxin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2JU49, Q4KLN2
      Related
      ENSRNOP00000068965.2, ENSRNOT00000086683.3
      Conserved Domains (2) summary
      cd03212
      Location:251 → 387
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      pfam10568
      Location:168 → 289
      Tom37; Outer mitochondrial membrane transport complex protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176913225..176919148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761135.3 → XP_008759357.1  metaxin-1 isoform X1

      UniProtKB/TrEMBL
      Q4KLN2
      Conserved Domains (2) summary
      cd03212
      Location:291 → 427
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      cd03078
      Location:150 → 223
      GST_N_Metaxin1_like; GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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