Atp6v1c1 ATPase H+ transporting V1 subunit C1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp6v1c1provided by RGD
Official Full Name: ATPase H+ transporting V1 subunit C1provided by RGD
Primary source: RGD:1311082
See related: EnsemblRapid:ENSRNOG00000004846 AllianceGenome:RGD:1311082
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification. Located in apical part of cell. Is extrinsic component of synaptic vesicle membrane. Orthologous to human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 614.4), Kidney (RPKM 396.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (71719326..71757191)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (69834464..69872278)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (77678853..77716658)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle lumen acidification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATPase complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in extrinsic component of synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of proton-transporting V-type ATPase complex	ISO Inferred from Sequence Orthology more info
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
part_of proton-transporting V-type ATPase, V1 domain	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: V-type proton ATPase subunit C 1

Names: ATPase, H+ transporting, V1 subunit C; ATPase, H+ transporting, lysosomal V1 subunit C1; V-ATPase subunit C 1; vacuolar proton pump subunit C 1

NP_001011992.1

EC 7.1.2.2

XP_006241664.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011992.1 → NP_001011992.1 V-type proton ATPase subunit C 1

See identical proteins and their annotated locations for NP_001011992.1

Status: PROVISIONAL

Source sequence(s)

BC089961

UniProtKB/Swiss-Prot

Q5FVI6

UniProtKB/TrEMBL

A0A8I5Y7J1

Related

ENSRNOP00000006917.4, ENSRNOT00000006917.7

Conserved Domains (2) summary

cd14785
Location:56 → 76

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:5 → 370

V-ATPase_C; V-ATPase subunit C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

71719326..71757191

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241602.5 → XP_006241664.1 V-type proton ATPase subunit C 1 isoform X1

UniProtKB/TrEMBL

A0A8I5Y7J1, A0A8I6GCD8

Related

ENSRNOP00000085031.1, ENSRNOT00000104331.2

Conserved Domains (2) summary

cd14785
Location:56 → 76

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:5 → 337

V-ATPase_C; V-ATPase subunit C