Atp6v0a2 ATPase H+ transporting V0 subunit a2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp6v0a2provided by RGD
Official Full Name: ATPase H+ transporting V0 subunit a2provided by RGD
Primary source: RGD:621006
See related: EnsemblRapid:ENSRNOG00000052704 AllianceGenome:RGD:621006
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tj6; J6b7; Cc1-3
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular response to increased oxygen levels and intracellular iron ion homeostasis. Predicted to be located in several cellular components, including acrosomal vesicle; focal adhesion; and perinuclear region of cytoplasm. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA and wrinkly skin syndrome. Orthologous to human ATP6V0A2 (ATPase H+ transporting V0 subunit a2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 113.8), Thymus (RPKM 105.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (37608211..37640860, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (31947220..31979875, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (37368321..37398233, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Voa1 and Voa2 cooperatively regulate the acidification and transmitter uptake/storage of dense-core vesicles, whereas they might not be as critical for exocytosis as recently proposed.
Title: Vacuolar H(+)-ATPase subunits Voa1 and Voa2 cooperatively regulate secretory vesicle acidification, transmitter uptake, and storage.

Submit: New GeneRIF Correction

General gene information

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Markers

BE110564 (e-PCR)
- UniSTS:245273

RH141592 (e-PCR)
- UniSTS:223586

RH141862 (e-PCR)
- UniSTS:223854

BF395959 (e-PCR)
- UniSTS:245457

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to increased oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of proton-transporting V-type ATPase complex	ISO Inferred from Sequence Orthology more info
part_of proton-transporting V-type ATPase, V0 domain	ISO Inferred from Sequence Orthology more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: V-type proton ATPase 116 kDa subunit a 2

Names: ATPase, H+ transporting, lysosomal V0 subunit A2; T-cell expressing clone j6; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a2

NP_446227.2

EC 7.1.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053775.4 → NP_446227.2 V-type proton ATPase 116 kDa subunit a 2

See identical proteins and their annotated locations for NP_446227.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

F1LQ38, Q2I6B1

Related

ENSRNOP00000068905.1, ENSRNOT00000083401.3

Conserved Domains (2) summary

COG1269
Location:5 → 839

NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

pfam01496
Location:28 → 839

V_ATPase_I; V-type ATPase 116kDa subunit family