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    Ildr2 immunoglobulin-like domain containing receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685277, updated on 9-Dec-2024

    Summary

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    Symbol
    Ildr2provided by RGD
    Full Name
    immunoglobulin-like domain containing receptor 2provided by RGD
    Primary source
    RGD:1596420
    See related
    EnsemblRapid:ENSRNOG00000025151 AllianceGenome:RGD:1596420
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of T cell activation; pancreas development; and regulation of RNA splicing. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; insulin secretion; and response to glucose. Predicted to be located in tight junction. Predicted to be active in membrane. Orthologous to human ILDR2 (immunoglobulin like domain containing receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 71.1), Kidney (RPKM 38.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ildr2 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (81051723..81113590)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78518770..78580627)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (84474191..84532347)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene glycoprotein A33 Neighboring gene cold shock domain-containing protein E1-like Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene uncharacterized LOC120096307 Neighboring gene uncharacterized LOC120096308 Neighboring gene transcriptional adaptor 1 Neighboring gene pogo transposable element derived with KRAB domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. Dokmanovic-Chouinard M, et al. PLoS Genet, 2008 Jul 25. PMID 18654634, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin-like domain-containing receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      81051723..81113590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769713.3 → XP_008767935.2  immunoglobulin-like domain-containing receptor 2 isoform X1

      UniProtKB/TrEMBL
      D3ZGJ1
      Related
      ENSRNOP00000036628.5, ENSRNOT00000031367.7
      Conserved Domains (2) summary
      pfam05624
      Location:186 → 212
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:36 → 166
      Ig; Immunoglobulin domain

    2. XM_017598996.3 → XP_017454485.1  immunoglobulin-like domain-containing receptor 2 isoform X2

      UniProtKB/TrEMBL
      D3ZGJ1
      Conserved Domains (2) summary
      pfam05624
      Location:170 → 196
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:18 → 129
      Ig; Immunoglobulin domain

    3. XM_008769716.4 → XP_008767938.1  immunoglobulin-like domain-containing receptor 2 isoform X2

      See identical proteins and their annotated locations for XP_008767938.1

      UniProtKB/TrEMBL
      D3ZGJ1
      Conserved Domains (2) summary
      pfam05624
      Location:170 → 196
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:18 → 129
      Ig; Immunoglobulin domain

    4. XM_017598997.3 → XP_017454486.1  immunoglobulin-like domain-containing receptor 2 isoform X2

      UniProtKB/TrEMBL
      D3ZGJ1
      Conserved Domains (2) summary
      pfam05624
      Location:170 → 196
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:18 → 129
      Ig; Immunoglobulin domain

    5. XM_039091405.1 → XP_038947333.1  immunoglobulin-like domain-containing receptor 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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