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    Stam2 signal transducing adaptor molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stam2provided by RGD
    Official Full Name
    signal transducing adaptor molecule 2provided by RGD
    Primary source
    RGD:1311497
    See related
    EnsemblRapid:ENSRNOG00000027447 AllianceGenome:RGD:1311497
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity and ubiquitin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in endocytic vesicle. Orthologous to human STAM2 (signal transducing adaptor molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 141.1), Kidney (RPKM 138.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stam2 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (57597557..57643915, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (37186145..37234810, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (38230676..38277433, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 5A Neighboring gene calcium voltage-gated channel auxiliary subunit beta 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transfer RNA serine (anticodon AGA) 35 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of hrs binding protein in IgE receptor-triggered exocytosis in RBL-2H3 mast cells. Murai S, et al. Biochem Biophys Res Commun, 2000 Nov 2. PMID 11062024
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal transducing adapter molecule 2
    Names
    STAM-2
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012085.1 → NP_001012085.1  signal transducing adapter molecule 2

      See identical proteins and their annotated locations for NP_001012085.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083912
      UniProtKB/Swiss-Prot
      Q5XHY7
      UniProtKB/TrEMBL
      A0A8I5ZKD5, A6JF29
      Related
      ENSRNOP00000080484.1, ENSRNOT00000115523.2
      Conserved Domains (4) summary
      cd11963
      Location:204 → 260
      SH3_STAM2; Src homology 3 domain of Signal Transducing Adaptor Molecule 2
      cd03568
      Location:9 → 143
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      pfam02809
      Location:166 → 181
      UIM; Ubiquitin interaction motif
      pfam03127
      Location:294 → 367
      GAT; GAT domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      57597557..57643915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XHY7.1 GenPept UniProtKB/Swiss-Prot:Q5XHY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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