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    Hk1 hexokinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25058, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hk1provided by RGD
    Official Full Name
    hexokinase 1provided by RGD
    Primary source
    RGD:2796
    See related
    EnsemblRapid:ENSRNOG00000046891 AllianceGenome:RGD:2796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HKI; HEXOKIN
    Summary
    Enables several functions, including ATP binding activity; D-glucose binding activity; and hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Located in caveola and mitochondrion. Part of protein-containing complex. Used to study obesity and urinary bladder cancer. Biomarker of colorectal cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 630.4), Brain (RPKM 381.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Hk1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (30773222..30874814, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30230488..30332099, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31911460..31979780, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene cytosolic iron-sulfur assembly component 2A, pseudogene 1 Neighboring gene tachykinin receptor 2 Neighboring gene synaptic defective enhancer 1-like Neighboring gene uncharacterized LOC134483920 Neighboring gene hexokinase domain containing 1 Neighboring gene Suv3 like RNA helicase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP hydrolysis activity PubMed 
    enables D-glucose binding PubMed 
    enables D-glucose binding  
    enables fructokinase activity  
    enables fructokinase activity PubMed 
    enables glucokinase activity  
    enables glucokinase activity PubMed 
    enables glucokinase activity  
    enables glucokinase activity  
    enables glucosamine kinase activity  
    enables hexokinase activity PubMed 
    enables hexokinase activity  
    enables hexokinase activity  
    enables identical protein binding PubMed 
    enables mannokinase activity  
    enables mannokinase activity PubMed 
    enables mannokinase activity  
    enables peptidoglycan binding  
    enables peptidoglycan binding  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process from glucose  
    involved_in GDP-mannose biosynthetic process from glucose  
    involved_in GDP-mannose biosynthetic process from mannose  
    involved_in GDP-mannose biosynthetic process from mannose  
    involved_in canonical glycolysis  
    involved_in canonical glycolysis  
    involved_in carbohydrate phosphorylation PubMed 
    involved_in carbohydrate phosphorylation  
    involved_in carbohydrate phosphorylation  
    involved_in establishment of protein localization to mitochondrion  
    involved_in establishment of protein localization to mitochondrion  
    involved_in fructose 6-phosphate metabolic process PubMed 
    involved_in glucose 6-phosphate metabolic process  
    involved_in glucose 6-phosphate metabolic process PubMed 
    involved_in glucose 6-phosphate metabolic process  
    involved_in glucose metabolic process  
    involved_in glycolytic process  
    involved_in glycolytic process PubMed 
    involved_in glycolytic process  
    involved_in hexose metabolic process  
    involved_in inflammatory response  
    involved_in innate immune response  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in maintenance of protein location in mitochondrion  
    involved_in maintenance of protein location in mitochondrion  
    involved_in mannose metabolic process PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of cytokine production involved in immune response  
    involved_in positive regulation of cytokine production involved in immune response  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in protein autophosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of anion channel activity PubMed 
    involved_in response to brassinosteroid PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to ischemia PubMed 
    involved_in response to ketamine PubMed 
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    located_in caveola PubMed 
    is_active_in cytosol  
    located_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in membrane raft  
    located_in membrane raft  
    located_in mitochondrial outer membrane  
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    hexokinase-1
    Names
    brain form hexokinase
    hexokinase type I
    hexokinase-A
    NP_001380640.1
    NP_036866.2
    XP_038954360.2
    XP_038954362.1
    XP_038954363.1
    XP_063135041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393711.1 → NP_001380640.1  hexokinase-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I5YBQ4
      Related
      ENSRNOP00000077266.1, ENSRNOT00000099595.2
      Conserved Domains (3) summary
      PTZ00107
      Location:23 → 464
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:473 → 671
      Hexokinase_1
      pfam03727
      Location:677 → 911
      Hexokinase_2
    2. NM_012734.2 → NP_036866.2  hexokinase-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P05708
      UniProtKB/TrEMBL
      A0A8I6AJ28
      Related
      ENSRNOP00000098666.1, ENSRNOT00000168329.1
      Conserved Domains (1) summary
      PTZ00107
      Location:462 → 907
      PTZ00107; hexokinase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      30773222..30874814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098432.2 → XP_038954360.2  hexokinase-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBQ4, A0A8I6AUZ1
      Related
      ENSRNOP00000097442.1, ENSRNOT00000112632.2
    2. XM_039098434.2 → XP_038954362.1  hexokinase-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBQ4
      Conserved Domains (3) summary
      PTZ00107
      Location:23 → 464
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:473 → 671
      Hexokinase_1
      pfam03727
      Location:677 → 911
      Hexokinase_2
    3. XM_039098435.2 → XP_038954363.1  hexokinase-1 isoform X3

      UniProtKB/Swiss-Prot
      P05708
      UniProtKB/TrEMBL
      A0A8I6ARQ9
      Related
      ENSRNOP00000097394.1, ENSRNOT00000105408.2
      Conserved Domains (3) summary
      PTZ00107
      Location:18 → 459
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:468 → 666
      Hexokinase_1
      pfam03727
      Location:672 → 906
      Hexokinase_2
    4. XM_063278971.1 → XP_063135041.1  hexokinase-1 isoform X4

      UniProtKB/Swiss-Prot
      P05708
      Related
      ENSRNOP00000093592.2, ENSRNOT00000115199.2
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