Adcy3 adenylate cyclase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy3provided by RGD
Official Full Name: adenylate cyclase 3provided by RGD
Primary source: RGD:71009
See related: EnsemblRapid:ENSRNOG00000003999 AllianceGenome:RGD:71009
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process and cellular response to forskolin. Located in several cellular components, including apical cytoplasm; dendritic knob; and sperm midpiece. Part of ciliary necklace. Biomarker of cardiomyopathy and diabetes mellitus. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 78.1), Thymus (RPKM 49.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6q14

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (32819602..32923174)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (27100089..27203686)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (28570941..28648848)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.
Title: Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.
Data suggest that type 3 adenylyl cyclase is primarily expressed in the small to medium sized cell bodies and central terminals of CGRP-positive dorsal root ganglion neurons.
Title: Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals.
The major components of the olfactory transduction pathway in the rat choroid plexus have been determined, including odorant receptors, Galphaolf, adenylate cyclase 3 and CNGA2.
Title: 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.
Here is formulated an active site model for the mammalian adenylyl cyclase class III, which is used to describe the potential surface along the reaction trajectory for enzyme-catalyzed conversion of ATP to cAMP.
Title: Catalytic Mechanism of Mammalian Adenylyl Cyclase: A Computational Investigation.
AC3 plays a role in regulation of glucose homeostasis via CNS and insulin secretion.
Title: Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis.
Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype.
Title: Adenylyl cyclases: expression in the developing rat thalamus and their role in absence epilepsy.
Data show that adenylate cyclase 3 type III is enriched in the ciliary membrane fraction.
Title: Scaffolding proteins in highly purified rat olfactory cilia membranes.
K(ATP) channels localize adenylyl cyclase to smooth muscle membrane fractions containing caveolin. To permit protein kinase A-dependent activation, arterial K(ATP) channels need to be in the same lipid compartment as adenylyl cyclase.
Title: Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
adenylyl cyclase 3 is functional in rodent oocytes and its activity is involved in the control of oocyte meiotic arrest
Title: Rodent oocytes express an active adenylyl cyclase required for meiotic arrest.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134597 (e-PCR)
- UniSTS:217877

UniSTS:496038 (e-PCR)
- UniSTS:496038

Adcy3 (e-PCR), detects polymorphism
- UniSTS:496038

ADCY3_1034 (e-PCR)
- UniSTS:276974

ADCY3_V295 (e-PCR)
- UniSTS:276974

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	TAS Traceable Author Statement more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	IEA Inferred from Electronic Annotation more info
involved_in acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in acrosome reaction	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to forskolin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	ISO Inferred from Sequence Orthology more info
involved_in olfactory learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
part_of ciliary necklace	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic knob	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 3

Names: AC-III; AC3; ATP pyrophosphate-lyase 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3; type III adenylyl cyclase

NP_570135.2

EC 4.6.1.1

XP_006239909.1

EC 4.6.1.1

XP_006239910.1

EC 4.6.1.1

XP_006239911.1

EC 4.6.1.1

XP_006239912.1

EC 4.6.1.1

XP_038968804.1

EC 4.6.1.1

XP_063118515.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130779.2 → NP_570135.2 adenylate cyclase type 3

See identical proteins and their annotated locations for NP_570135.2

Status: PROVISIONAL

Source sequence(s)

AW525494, CB720821, M55075

UniProtKB/Swiss-Prot

P21932

UniProtKB/TrEMBL

A6HAH1, G3V6I2

Conserved Domains (2) summary

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

32819602..32923174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112876.2 → XP_038968804.1 adenylate cyclase type 3 isoform X1

UniProtKB/Swiss-Prot

P21932

UniProtKB/TrEMBL

A6HAH1, G3V6I2

Conserved Domains (2) summary

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_006239847.5 → XP_006239909.1 adenylate cyclase type 3 isoform X1

See identical proteins and their annotated locations for XP_006239909.1

UniProtKB/Swiss-Prot

P21932

UniProtKB/TrEMBL

A6HAH1, G3V6I2

Conserved Domains (2) summary

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_063262445.1 → XP_063118515.1 adenylate cyclase type 3 isoform X2

UniProtKB/Swiss-Prot

P21932
XM_006239848.5 → XP_006239910.1 adenylate cyclase type 3 isoform X1

See identical proteins and their annotated locations for XP_006239910.1

UniProtKB/Swiss-Prot

P21932

UniProtKB/TrEMBL

A6HAH1, G3V6I2

Conserved Domains (2) summary

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_006239849.5 → XP_006239911.1 adenylate cyclase type 3 isoform X1

See identical proteins and their annotated locations for XP_006239911.1

UniProtKB/Swiss-Prot

P21932

UniProtKB/TrEMBL

A6HAH1, G3V6I2

Related

ENSRNOP00000005389.4, ENSRNOT00000005389.8

Conserved Domains (2) summary

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_006239850.5 → XP_006239912.1 adenylate cyclase type 3 isoform X2

UniProtKB/Swiss-Prot

P21932

Conserved Domains (3) summary

smart00044
Location:882 → 1100

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:913 → 1120

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region