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    Msh3 mutS homolog 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499505, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Msh3provided by RGD
    Official Full Name
    mutS homolog 3provided by RGD
    Primary source
    RGD:1563954
    See related
    EnsemblRapid:ENSRNOG00000064838 AllianceGenome:RGD:1563954
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable centromeric DNA binding activity; damaged DNA binding activity; and enzyme binding activity. Predicted to contribute to dinucleotide repeat insertion binding activity; single guanine insertion binding activity; and single-stranded DNA binding activity. Involved in spermatogenesis. Predicted to be located in nucleus. Predicted to be part of MutSbeta complex. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 65.1), Liver (RPKM 64.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msh3 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (25179400..25320857, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (23444326..23585777, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (21790048..21931791, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene RAS protein-specific guanine nucleotide-releasing factor 2 Neighboring gene dihydrofolate reductase Neighboring gene ankyrin repeat domain 34B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. Yin J, et al. Hum Mutat, 1997. PMID 9401011
    2. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Edelmann W, et al. Cancer Res, 2000 Feb 15. PMID 10706084
    3. Cloning of rat MLH1 and expression analysis of MSH2, MSH3, MSH6, and MLH1 during spermatogenesis. Geeta Vani R, et al. Genomics, 1999 Dec 15. PMID 10644444
    4. Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. Li Z, et al. J Exp Med, 2004 Jul 5. PMID 15238604, Free PMC Article
    5. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Risinger JI, et al. Nat Genet, 1996 Sep. PMID 8782829

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables centromeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to dinucleotide insertion or deletion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to dinucleotide repeat insertion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables guanine/thymine mispair binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to mismatched DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT contributes_to oxidized purine DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single guanine insertion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of DNA repeat elements ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic recombination of immunoglobulin gene segments ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutSbeta complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA mismatch repair protein Msh3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191957.1 → NP_001178886.1  DNA mismatch repair protein Msh3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000109273.1, ENSRNOT00000172709.1
      Conserved Domains (6) summary
      COG0249
      Location:183 → 1053
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam00488
      Location:804 → 1052
      MutS_V; MutS domain V
      pfam01624
      Location:188 → 301
      MutS_I; MutS domain I
      pfam05188
      Location:324 → 481
      MutS_II; MutS domain II
      pfam05192
      Location:498 → 613
      MutS_III; MutS domain III
      cl17822
      Location:670 → 741
      MutS_III; MutS domain III

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      25179400..25320857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282328.1 → XP_063138398.1  DNA mismatch repair protein Msh3 isoform X4

    2. XM_063282327.1 → XP_063138397.1  DNA mismatch repair protein Msh3 isoform X3

    3. XM_063282326.1 → XP_063138396.1  DNA mismatch repair protein Msh3 isoform X2

    4. XM_063282325.1 → XP_063138395.1  DNA mismatch repair protein Msh3 isoform X1

    5. XM_063282329.1 → XP_063138399.1  DNA mismatch repair protein Msh3 isoform X5

    6. XM_063282335.1 → XP_063138405.1  DNA mismatch repair protein Msh3 isoform X10

    7. XM_063282333.1 → XP_063138403.1  DNA mismatch repair protein Msh3 isoform X9

    8. XM_063282330.1 → XP_063138400.1  DNA mismatch repair protein Msh3 isoform X6

      UniProtKB/TrEMBL
      A6I4Q5

    9. XM_063282332.1 → XP_063138402.1  DNA mismatch repair protein Msh3 isoform X8

      UniProtKB/TrEMBL
      A6I4Q5

    10. XM_063282331.1 → XP_063138401.1  DNA mismatch repair protein Msh3 isoform X7

      UniProtKB/TrEMBL
      A6I4Q5
    Nucleotide Protein Strain
    Heading Accession and Version

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