Syf2 SYF2 pre-mRNA-splicing factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Syf2provided by RGD
Official Full Name: SYF2 pre-mRNA-splicing factorprovided by RGD
Primary source: RGD:621592
See related: AllianceGenome:RGD:621592
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P29; Gcipip
Summary: Involved in positive regulation of cell population proliferation. Predicted to be located in nuclear speck. Predicted to be part of Prp19 complex; U2-type catalytic step 2 spliceosome; and post-mRNA release spliceosomal complex. Biomarker of encephalitis. Orthologous to human SYF2 (SYF2 pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 365.9), Lung (RPKM 352.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (152440171..152448094)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (147156492..147164416)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (153269638..153277562)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYF2 protein expression was dramatically upregulated after retinal damage.
Title: Upregulation of SYF2 Relates to Retinal Ganglion Cell Apoptosis and Retinal Glia Cell Proliferation After Light-Induced Retinal Damage.
the upregulation of SYF2 was associated with Schwann cell differentiation and migration following sciatic nerve crush.
Title: Involvement of upregulated SYF2 in Schwann cell differentiation and migration after sciatic nerve crush.
This study shows that SYF2 was significantly increased in the rat cerebral cortex after LPS injection, suggesting that SYF2 might be involved in the pathological processes of astrocyte proliferation and neuronal apoptosis.
Title: Upregulation of SYF2 is associated with neuronal apoptosis caused by reactive astrogliosis to neuroinflammation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138591 (e-PCR)
- UniSTS:220678

RH139392 (e-PCR)
- UniSTS:221478

RH142753 (e-PCR)
- UniSTS:232000

RH129579 (e-PCR)
- UniSTS:212880

RH129320 (e-PCR)
- UniSTS:212627

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type catalytic step 2 spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pre-mRNA-splicing factor SYF2

Names: GCIP-interacting protein p29; SYF2 homolog, RNA splicing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133417.2 → NP_596908.2 pre-mRNA-splicing factor SYF2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q4QRB2, Q91Y33

Conserved Domains (1) summary

pfam08231
Location:89 → 237

SYF2; SYF2 splicing factor