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    Egr2 early growth response 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114090, updated on 31-Dec-2024

    Summary

    Official Symbol
    Egr2provided by RGD
    Official Full Name
    early growth response 2provided by RGD
    Primary source
    RGD:621608
    See related
    EnsemblRapid:ENSRNOG00000000640 AllianceGenome:RGD:621608
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Krox20
    Summary
    Enables HMG box domain binding activity. Involved in learning or memory; regulation of neuronal synaptic plasticity; and response to insulin. Predicted to be located in cytoplasm and nucleoplasm. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 20.8), Lung (RPKM 7.6) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Egr2 in Genome Data Viewer
    Location:
    20p11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (21050149..21055201, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (21051270..21056322, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (22452170..22461018, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349059 Neighboring gene 2-aminoethanethiol dioxygenase Neighboring gene uncharacterized LOC108349024 Neighboring gene uncharacterized LOC120098947

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables HMG box domain binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables SUMO ligase activity  
    enables chromatin binding  
    enables chromatin binding  
    enables metal ion binding  
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 43
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell differentiation  
    involved_in Schwann cell differentiation  
    involved_in Schwann cell differentiation  
    involved_in aorta development  
    acts_upstream_of_or_within brain segmentation  
    acts_upstream_of_or_within facial nerve structural organization  
    involved_in facial nerve structural organization  
    involved_in facial nerve structural organization  
    involved_in fat cell differentiation  
    acts_upstream_of_or_within_negative_effect gene expression  
    involved_in gene expression  
    involved_in learning or memory PubMed 
    acts_upstream_of_or_within motor neuron axon guidance  
    acts_upstream_of_or_within myelination  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of Schwann cell differentiation  
    involved_in positive regulation of Schwann cell differentiation  
    involved_in positive regulation of myelination  
    involved_in positive regulation of myelination  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein export from nucleus  
    involved_in protein export from nucleus  
    involved_in protein sumoylation  
    involved_in protein sumoylation  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of neuronal synaptic plasticity PubMed 
    acts_upstream_of_or_within regulation of ossification  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to insulin PubMed 
    acts_upstream_of_or_within rhombomere 3 development  
    acts_upstream_of_or_within rhombomere 3 formation  
    involved_in rhombomere 3 structural organization  
    involved_in rhombomere 3 structural organization  
    acts_upstream_of_or_within rhombomere 5 formation  
    involved_in rhombomere 5 structural organization  
    involved_in rhombomere 5 structural organization  
    acts_upstream_of_or_within rhythmic behavior  
    acts_upstream_of_or_within skeletal muscle cell differentiation  
    involved_in skeletal muscle cell differentiation  
    involved_in skeletal muscle cell differentiation  
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    E3 SUMO-protein ligase EGR2
    Names
    E3 SUMO-protein transferase ERG2
    EGR-2
    early growth response protein 2
    zinc finger protein Krox-20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053633.2NP_446085.1  E3 SUMO-protein ligase EGR2

      See identical proteins and their annotated locations for NP_446085.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P51774, Q54AG4
      UniProtKB/TrEMBL
      A6JKW0, A6JKW1
      Related
      ENSRNOP00000000792.2, ENSRNOT00000000792.6
      Conserved Domains (4) summary
      COG5048
      Location:365421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:337361
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:94166
      DUF3446; Domain of unknown function (DUF3446)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      21050149..21055201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601530.2XP_017457019.1  E3 SUMO-protein ligase EGR2 isoform X1

      UniProtKB/TrEMBL
      A6JKW2, Q9QYG4
      Conserved Domains (5) summary
      COG5048
      Location:315371
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:287311
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:44116
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:331356
      zf-H2C2_2; Zinc-finger double domain
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