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    Ccz1 CCZ1 homolog, vacuolar protein trafficking and biogenesis associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccz1provided by RGD
    Official Full Name
    CCZ1 homolog, vacuolar protein trafficking and biogenesis associatedprovided by RGD
    Primary source
    RGD:1306410
    See related
    EnsemblRapid:ENSRNOG00000001032 AllianceGenome:RGD:1306410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccz1b; RGD1306410
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in lysosomal membrane. Predicted to be part of Mon1-Ccz1 complex. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to several human genes including CCZ1B (CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 174.2), Spleen (RPKM 157.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccz1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15714768..15738273)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10601066..10624608)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12638849..12662371)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene lemur tyrosine kinase 2 Neighboring gene elongation factor 1-gamma-like Neighboring gene oncomodulin Neighboring gene radial spoke head 10 homolog B Neighboring gene small nucleolar RNA SNORA51 Neighboring gene PMS1 homolog 2, mismatch repair system component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux. Vaites LP, et al. Mol Cell Biol, 2018 Jan 1. PMID 29038162, Free PMC Article
    2. BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor. Gerondopoulos A, et al. Curr Biol, 2012 Nov 20. PMID 23084991, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar fusion protein CCZ1 homolog
    Names
    CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated
    CCZ1 homolog, vacuolar protein trafficking and biogenesis associated B
    CCZ1 vacuolar protein trafficking and biogenesis associated homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394280.1 → NP_001381209.1  vacuolar fusion protein CCZ1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A0G2JUB1, A0A140UHX9
      Related
      ENSRNOP00000001365.6, ENSRNOT00000001365.9
      Conserved Domains (1) summary
      pfam08217
      Location:25 → 477
      DUF1712; Fungal domain of unknown function (DUF1712)

    2. NM_001394281.1 → NP_001381210.1  vacuolar fusion protein CCZ1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      Conserved Domains (1) summary
      pfam08217
      Location:25 → 424
      DUF1712; Fungal domain of unknown function (DUF1712)

    RNA

    1. NR_172093.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      Related
      ENSRNOT00000092587.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15714768..15738273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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