Ptpra protein tyrosine phosphatase, receptor type, A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptpraprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Aprovided by RGD
Primary source: RGD:3450
See related: EnsemblRapid:ENSRNOG00000021223 AllianceGenome:RGD:3450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRP
Summary: Enables protein tyrosine phosphatase activity. Involved in oligodendrocyte differentiation and positive regulation of oligodendrocyte differentiation. Predicted to be located in focal adhesion and membrane. Predicted to be part of receptor complex. Predicted to be active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 291.6), Heart (RPKM 200.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138103261..138212835)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117650146..117759744)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (122976066..123084585)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation
Title: Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha.
CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity.
Title: Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
protein tyrosine phosphatase PTP alpha has a role in induction of src kinase via protein kinase C
Title: Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134950 (e-PCR)
- UniSTS:218227

AU047115 (e-PCR)
- UniSTS:110826

BE108511 (e-PCR)
- UniSTS:247787

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase alpha

Names: R-PTP-alpha; protein tyrosine phosphatase alpha

NP_036895.2

EC 3.1.3.48

XP_006235068.1

EC 3.1.3.48

XP_038960268.1

EC 3.1.3.48

XP_063139209.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012763.2 → NP_036895.2 receptor-type tyrosine-protein phosphatase alpha precursor

See identical proteins and their annotated locations for NP_036895.2

Status: PROVISIONAL

Source sequence(s)

BC081828

UniProtKB/Swiss-Prot

Q03348

UniProtKB/TrEMBL

F1M833, Q66HJ7

Related

ENSRNOP00000109915.1, ENSRNOT00000162829.1

Conserved Domains (3) summary

PHA03255
Location:18 → 169

PHA03255; BDLF3; Provisional

smart00194
Location:526 → 784

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:554 → 784

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

138103261..138212835

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235006.5 → XP_006235068.1 receptor-type tyrosine-protein phosphatase alpha isoform X1

See identical proteins and their annotated locations for XP_006235068.1

UniProtKB/Swiss-Prot

Q03348

UniProtKB/TrEMBL

A0A8J8YBN3

Related

ENSRNOP00000103665.1, ENSRNOT00000147780.1

Conserved Domains (3) summary

PHA03255
Location:18 → 177

PHA03255; BDLF3; Provisional

cd14621
Location:217 → 512

R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1

cd14623
Location:566 → 793

R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
XM_039104340.2 → XP_038960268.1 receptor-type tyrosine-protein phosphatase alpha isoform X1

UniProtKB/Swiss-Prot

Q03348

UniProtKB/TrEMBL

A0A8J8YBN3

Conserved Domains (3) summary

PHA03255
Location:18 → 177

PHA03255; BDLF3; Provisional

cd14621
Location:217 → 512

R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1

cd14623
Location:566 → 793

R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
XM_063283139.1 → XP_063139209.1 receptor-type tyrosine-protein phosphatase alpha isoform X2