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    Arfip1 ARF interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arfip1provided by RGD
    Official Full Name
    ARF interacting protein 1provided by RGD
    Primary source
    RGD:708401
    See related
    EnsemblRapid:ENSRNOG00000010533 AllianceGenome:RGD:708401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in intracellular protein transport; negative regulation of retrograde transport, endosome to Golgi; and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within regulation of protein secretion. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in trans-Golgi network membrane. Orthologous to human ARFIP1 (ADP ribosylation factor interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 148.5), Lung (RPKM 145.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arfip1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (172141862..172224464, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169843804..169924136, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (183503250..183582798, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485931 Neighboring gene uncharacterized LOC120100858 Neighboring gene FH2 domain containing 1 Neighboring gene tigger transposable element derived 4 Neighboring gene transmembrane protein 154

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arfaptin-1 negatively regulates Arl1-mediated retrograde transport. Huang LH, et al. PLoS One, 2015. PMID 25789876, Free PMC Article
    2. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. Ho WT, et al. FEBS Lett, 2003 Feb 27. PMID 12606037
    3. The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network. Gehart H, et al. Dev Cell, 2012 Oct 16. PMID 22981988
    4. Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. Cruz-Garcia D, et al. EMBO J, 2013 Jun 12. PMID 23695357, Free PMC Article
    5. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. Kanoh H, et al. J Biol Chem, 1997 Feb 28. PMID 9038142

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arfaptin-1
    Names
    ADP-ribosylation factor interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021763.2 → NP_068531.1  arfaptin-1

      See identical proteins and their annotated locations for NP_068531.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9JHU5
      UniProtKB/TrEMBL
      A0A0G2JYA2, A6J5W8
      Conserved Domains (2) summary
      cd07660
      Location:148 → 348
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
      pfam07490
      Location:28 → 110
      Tir_receptor_N; Translocated intimin receptor (Tir) N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      172141862..172224464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232545.5 → XP_006232607.1  arfaptin-1 isoform X3

      See identical proteins and their annotated locations for XP_006232607.1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8I6ACN3
      Related
      ENSRNOP00000089444.2, ENSRNOT00000100457.2
      Conserved Domains (1) summary
      cd07660
      Location:123 → 323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    2. XM_006232539.5 → XP_006232601.1  arfaptin-1 isoform X1

      See identical proteins and their annotated locations for XP_006232601.1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0
      Related
      ENSRNOP00000014236.5, ENSRNOT00000014236.8
      Conserved Domains (1) summary
      cd07660
      Location:155 → 355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    3. XM_039103009.2 → XP_038958937.1  arfaptin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0
      Conserved Domains (1) summary
      cd07660
      Location:155 → 355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    4. XM_006232546.5 → XP_006232608.1  arfaptin-1 isoform X3

      See identical proteins and their annotated locations for XP_006232608.1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8I6ACN3
      Conserved Domains (1) summary
      cd07660
      Location:123 → 323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    5. XM_063282433.1 → XP_063138503.1  arfaptin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q9JHU5
      UniProtKB/TrEMBL
      A0A0G2JYA2, A6J5W8

    6. XM_006232540.5 → XP_006232602.1  arfaptin-1 isoform X1

      See identical proteins and their annotated locations for XP_006232602.1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0
      Conserved Domains (1) summary
      cd07660
      Location:155 → 355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    7. XM_039103010.2 → XP_038958938.1  arfaptin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0
      Conserved Domains (1) summary
      cd07660
      Location:155 → 355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    8. XM_063282434.1 → XP_063138504.1  arfaptin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q9JHU5
      UniProtKB/TrEMBL
      A0A0G2JYA2, A6J5W8

    9. XM_063282430.1 → XP_063138500.1  arfaptin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0

    10. XM_063282436.1 → XP_063138506.1  arfaptin-1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8I6ACN3

    11. XM_017591062.3 → XP_017446551.1  arfaptin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0
      Conserved Domains (1) summary
      cd07660
      Location:155 → 355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    12. XM_063282435.1 → XP_063138505.1  arfaptin-1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8I6ACN3

    13. XM_063282432.1 → XP_063138502.1  arfaptin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0

    14. XM_063282431.1 → XP_063138501.1  arfaptin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA2, A0A8L2Q6T7, A6J5X0

    15. XM_039103012.1 → XP_038958940.1  arfaptin-1 isoform X5

      Conserved Domains (1) summary
      cd07660
      Location:34 → 234
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    16. XM_063282438.1 → XP_063138508.1  arfaptin-1 isoform X5

    17. XM_063282437.1 → XP_063138507.1  arfaptin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZL02

    18. XM_039103013.2 → XP_038958941.1  arfaptin-1 isoform X6

      Conserved Domains (1) summary
      cl12013
      Location:134 → 211
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHU5.1 GenPept UniProtKB/Swiss-Prot:Q9JHU5

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