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    Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Herc1provided by RGD
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase family member 1provided by RGD
    Primary source
    RGD:1306366
    See related
    EnsemblRapid:ENSRNOG00000051671 AllianceGenome:RGD:1306366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to act upstream of or within negative regulation of autophagy; nervous system development; and neuromuscular process controlling balance. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 351.7), Spleen (RPKM 349.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Herc1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75796347..75965347)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66857169..67070318)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72029550..72198363)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene death-associated protein kinase 2 Neighboring gene uncharacterized LOC108351731 Neighboring gene uncharacterized LOC134480197 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene uncharacterized LOC120094375

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase. Mashimo T, et al. PLoS Genet, 2009 Dec. PMID 20041218, Free PMC Article
    2. The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation. Schneider T, et al. Oncotarget, 2018 Jul 31. PMID 30140388, Free PMC Article
    3. Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice. Rossi F, et al. J Neurosci, 1995 Mar. PMID 7891151, Free PMC Article
    4. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within corpus callosum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HERC1
    Names
    hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
    NP_001407845.1
    XP_017451567.1
    XP_038938405.1
    XP_063121593.1
    XP_063121594.1
    XP_063121595.1
    XP_063121596.1
    XP_063121597.1
    XP_063121598.1
    XP_063121599.1
    XP_063121600.1
    XP_063121601.1
    XP_063121602.1
    XP_063121603.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420916.1 → NP_001407845.1  probable E3 ubiquitin-protein ligase HERC1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JTT6, A0A8I5ZV70

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75796347..75965347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265523.1 → XP_063121593.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV70

    2. XM_063265529.1 → XP_063121599.1  probable E3 ubiquitin-protein ligase HERC1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZV70

    3. XM_063265525.1 → XP_063121595.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZV70

    4. XM_063265531.1 → XP_063121601.1  probable E3 ubiquitin-protein ligase HERC1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZV70

    5. XM_063265527.1 → XP_063121597.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZV70

    6. XM_063265524.1 → XP_063121594.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV70

    7. XM_063265526.1 → XP_063121596.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZV70

    8. XM_063265528.1 → XP_063121598.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZV70

    9. XM_017596078.3 → XP_017451567.1  probable E3 ubiquitin-protein ligase HERC1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZV70
      Related
      ENSRNOP00000068838.3, ENSRNOT00000089336.3
      Conserved Domains (9) summary
      smart00119
      Location:4519 → 4852
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      COG2319
      Location:3409 → 3793
      WD40; WD40 repeat [General function prediction only]
      cd00078
      Location:4488 → 4856
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2751 → 2794
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      pfam00415
      Location:4115 → 4164
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:4308 → 4337
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
      sd00039
      Location:3447 → 3490
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2030 → 2187
      SPRY_HERC1; SPRY domain in HERC1
      cl02567
      Location:3439 → 3790
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_063265532.1 → XP_063121602.1  probable E3 ubiquitin-protein ligase HERC1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZV70

    11. XM_063265530.1 → XP_063121600.1  probable E3 ubiquitin-protein ligase HERC1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZV70

    12. XM_063265533.1 → XP_063121603.1  probable E3 ubiquitin-protein ligase HERC1 isoform X13

    13. XM_039082477.1 → XP_038938405.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

      UniProtKB/TrEMBL
      A6J5I1
      Conserved Domains (6) summary
      COG5184
      Location:2683 → 3031
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:3158 → 3526
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:1421 → 1464
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:2117 → 2160
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:700 → 857
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:2109 → 2460
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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