Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnajc3provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member C3provided by RGD
Primary source: RGD:708518
See related: EnsemblRapid:ENSRNOG00000010352 AllianceGenome:RGD:708518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including misfolded protein binding activity; protein kinase inhibitor activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including cellular response to cold; protein folding in endoplasmic reticulum; and regulation of translational initiation. Located in smooth endoplasmic reticulum. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1194.3), Kidney (RPKM 477.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (102432667..102475643)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (96025605..96068585)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (104186918..104226236)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endoplasmic reticulum stress activation and p58(IPK) expression control the fate of malignant cells facing glucose shortage.
Title: p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose.
P58(IPK) may act as a diabetic retinopathy -resistant gene during diabetes
Title: Functional characterization of 58-kilodalton inhibitor of protein kinase in protecting against diabetic retinopathy via the endoplasmic reticulum stress pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH125510 (e-PCR)
- UniSTS:162328

RH128467 (e-PCR)
- UniSTS:211775

S100a10 (e-PCR), detects polymorphism
- UniSTS:507204

S100a10 (e-PCR), detects polymorphism
- UniSTS:465493

RH124908 (e-PCR)
- UniSTS:161730

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables misfolded protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cold	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cold	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation initiation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation initiation in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dnaJ homolog subfamily C member 3

Names: DnaJ (Hsp40) homolog, subfamily C, member 3; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.