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    Dag1 dystroglycan 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114489, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dag1provided by RGD
    Official Full Name
    dystroglycan 1provided by RGD
    Primary source
    RGD:621890
    See related
    EnsemblRapid:ENSRNOG00000019400 AllianceGenome:RGD:621890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; nervous system development; and regulation of nervous system development. Located in several cellular components, including basolateral plasma membrane; costamere; and focal adhesion. Part of dystrophin-associated glycoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cholangitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 675.3), Heart (RPKM 576.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dag1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117769517..117834347, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108890926..108955611, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116980501..116993182, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene bassoon (presynaptic cytomatrix protein) Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 3 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene aminomethyltransferase Neighboring gene T-cell leukemia translocation altered Neighboring gene ras homolog family member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding  
    enables actin binding  
    enables alpha-actinin binding  
    enables calcium ion binding  
    enables dystroglycan binding  
    enables laminin binding  
    enables laminin binding PubMed 
    enables laminin binding  
    enables laminin-1 binding PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables structural constituent of muscle  
    enables tubulin binding  
    enables vinculin binding  
    enables virus receptor activity  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in Schwann cell development  
    involved_in Schwann cell differentiation PubMed 
    involved_in angiogenesis involved in wound healing PubMed 
    involved_in axon guidance  
    involved_in axon regeneration PubMed 
    acts_upstream_of_or_within basement membrane organization  
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis  
    involved_in calcium-dependent cell-matrix adhesion PubMed 
    involved_in cellular response to cholesterol PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    acts_upstream_of_or_within commissural neuron axon guidance  
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis  
    acts_upstream_of_or_within heart development  
    acts_upstream_of_or_within heart morphogenesis  
    involved_in membrane protein ectodomain proteolysis  
    involved_in microtubule anchoring  
    acts_upstream_of_or_within morphogenesis of an epithelial sheet  
    involved_in morphogenesis of an epithelium  
    involved_in muscle attachment  
    involved_in myelination in peripheral nervous system  
    involved_in negative regulation of MAPK cascade  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in nerve development  
    involved_in nerve development PubMed 
    involved_in nerve maturation  
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
    involved_in positive regulation of cell-matrix adhesion PubMed 
    involved_in positive regulation of myelination PubMed 
    involved_in positive regulation of oligodendrocyte differentiation PubMed 
    involved_in positive regulation of protein kinase activity PubMed 
    acts_upstream_of_or_within protein transport  
    involved_in regulation of epithelial to mesenchymal transition  
    involved_in regulation of gastrulation  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  
    involved_in regulation of synapse organization  
    acts_upstream_of_or_within regulation of synaptic plasticity  
    involved_in response to denervation involved in regulation of muscle adaptation PubMed 
    acts_upstream_of_or_within response to muscle activity  
    involved_in response to peptide hormone PubMed 
    involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex  
    involved_in skeletal muscle tissue regeneration PubMed 
    involved_in symbiont entry into host cell  
    Items 1 - 25 of 44
    Items 1 - 20 of 42
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in adherens junction PubMed 
    is_active_in basement membrane  
    located_in basement membrane  
    located_in basolateral plasma membrane PubMed 
    is_active_in cell surface  
    located_in cell-cell junction  
    located_in contractile ring  
    located_in costamere PubMed 
    located_in cytoplasm  
    located_in cytoskeleton  
    part_of dystroglycan complex  
    part_of dystroglycan complex  
    part_of dystrophin-associated glycoprotein complex PubMed 
    part_of dystrophin-associated glycoprotein complex  
    located_in external side of plasma membrane  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in filopodium  
    located_in focal adhesion PubMed 
    located_in focal adhesion  
    is_active_in glutamatergic synapse PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in lamellipodium  
    located_in membrane  
    located_in membrane raft  
    located_in node of Ranvier  
    located_in nuclear periphery PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in photoreceptor ribbon synapse  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane raft PubMed 
    is_active_in postsynapse  
    is_active_in postsynaptic cytosol PubMed 
    located_in postsynaptic membrane  
    is_active_in sarcolemma  
    located_in sarcolemma PubMed 
    located_in sarcolemma  
    Items 1 - 20 of 42

    General protein information

    Preferred Names
    dystroglycan 1
    Names
    alpha-dystroglycan
    beta-dystroglycan
    dystroglycan 1 (dystrophin-associated glycoprotein 1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053697.1NP_446149.1  dystroglycan 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F1M8K0
      Related
      ENSRNOP00000026327.4, ENSRNOT00000026327.9
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117769517..117834347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080666.2XP_038936594.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
    2. XM_039080670.2XP_038936598.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
    3. XM_039080664.2XP_038936592.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
    4. XM_039080669.2XP_038936597.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
    5. XM_039080665.2XP_038936593.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
    6. XM_039080672.2XP_038936600.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
    7. XM_039080668.2XP_038936596.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
    8. XM_039080667.2XP_038936595.1  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1M8K0
      Conserved Domains (4) summary
      cd11303
      Location:60161
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      PRK14971
      Location:311402
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam05454
      Location:604893
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      pfam18424
      Location:180302
      a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
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