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    Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298573, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif4g3provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4 gamma, 3provided by RGD
    Primary source
    RGD:1311370
    See related
    EnsemblRapid:ENSRNOG00000014368 AllianceGenome:RGD:1311370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in spermatid development and translational initiation. Predicted to act upstream of or within positive regulation of meiosis I; positive regulation of protein metabolic process; and spermatogenesis. Predicted to be part of eukaryotic translation initiation factor 4F complex. Predicted to be active in intracellular non-membrane-bounded organelle and synapse. Orthologous to human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 175.1), Testes (RPKM 169.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eif4g3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155481378..155702194)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150197410..150418862)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156343663..156564037)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487019 Neighboring gene U4 spliceosomal RNA Neighboring gene endothelin converting enzyme 1 Neighboring gene uncharacterized LOC102553758 Neighboring gene uncharacterized LOC134487020 Neighboring gene macrophage migration inhibitory factor, pseudogene 5 Neighboring gene heterochromatin protein 1, binding protein 3

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    NOT involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in intracellular membraneless organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4 gamma 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106693.1NP_001100163.1  eukaryotic translation initiation factor 4 gamma 3 isoform 1

      See identical proteins and their annotated locations for NP_001100163.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ITF4, A6ITF5, D4A554
      Related
      ENSRNOP00000070544.1, ENSRNOT00000090232.3
      Conserved Domains (4) summary
      cd11559
      Location:14221554
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12531365
      MA3; MA3 domain
      pfam02854
      Location:7871015
      MIF4G; MIF4G domain
      cl17013
      Location:15331579
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    2. NM_001401860.1NP_001388789.1  eukaryotic translation initiation factor 4 gamma 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A423
      Related
      ENSRNOP00000084998.2, ENSRNOT00000103027.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155481378..155702194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287466.1XP_063143536.1  eukaryotic translation initiation factor 4 gamma 3 isoform X42

      UniProtKB/TrEMBL
      A0A8I6A423
    2. XM_017593294.3XP_017448783.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6APR0
    3. XM_017593298.3XP_017448787.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

      UniProtKB/TrEMBL
      A0A8I6APR0
    4. XM_008764221.4XP_008762443.2  eukaryotic translation initiation factor 4 gamma 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6APR0
    5. XM_063287460.1XP_063143530.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

      UniProtKB/TrEMBL
      A0A8I6APR0
    6. XM_063287456.1XP_063143526.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6APR0
    7. XM_063287457.1XP_063143527.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6APR0
      Related
      ENSRNOP00000080944.1, ENSRNOT00000103555.2
    8. XM_039109651.2XP_038965579.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

      UniProtKB/TrEMBL
      A0A8I6APR0
      Related
      ENSRNOP00000087364.2, ENSRNOT00000115071.2
      Conserved Domains (5) summary
      cd11559
      Location:16071739
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:65487
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14051517
      MA3; MA3 domain
      pfam02854
      Location:9581186
      MIF4G; MIF4G domain
      cl17013
      Location:17181764
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    9. XM_008764222.4XP_008762444.2  eukaryotic translation initiation factor 4 gamma 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I6APR0
    10. XM_063287459.1XP_063143529.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

      UniProtKB/TrEMBL
      A0A8I6APR0
    11. XM_063287465.1XP_063143535.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

      UniProtKB/TrEMBL
      A0A8I6APR0
      Related
      ENSRNOP00000095940.2, ENSRNOT00000112319.2
    12. XM_063287463.1XP_063143533.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

      UniProtKB/TrEMBL
      A0A8I6APR0
      Related
      ENSRNOP00000096026.2, ENSRNOT00000098443.2
    13. XM_063287464.1XP_063143534.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

      UniProtKB/TrEMBL
      A0A8I6APR0
    14. XM_063287462.1XP_063143532.1  eukaryotic translation initiation factor 4 gamma 3 isoform X28

      UniProtKB/TrEMBL
      A0A8I6APR0
    15. XM_039109643.2XP_038965571.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65498
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14351547
      MA3; MA3 domain
      pfam02854
      Location:9691197
      MIF4G; MIF4G domain
    16. XM_039109649.2XP_038965577.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65498
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14161528
      MA3; MA3 domain
      pfam02854
      Location:9691197
      MIF4G; MIF4G domain
    17. XM_039109644.2XP_038965572.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:70546
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14341546
      MA3; MA3 domain
      pfam02854
      Location:9681196
      MIF4G; MIF4G domain
    18. XM_063287458.1XP_063143528.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

      UniProtKB/TrEMBL
      A0A8I6APR0
    19. XM_039109645.2XP_038965573.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65491
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14281540
      MA3; MA3 domain
      pfam02854
      Location:9621190
      MIF4G; MIF4G domain
    20. XM_039109647.2XP_038965575.1  eukaryotic translation initiation factor 4 gamma 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65487
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14241536
      MA3; MA3 domain
      pfam02854
      Location:9581186
      MIF4G; MIF4G domain
    21. XM_039109648.2XP_038965576.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65480
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14171529
      MA3; MA3 domain
      pfam02854
      Location:9511179
      MIF4G; MIF4G domain
    22. XM_039109650.2XP_038965578.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65470
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13971509
      MA3; MA3 domain
      pfam02854
      Location:9311159
      MIF4G; MIF4G domain
    23. XM_039109653.2XP_038965581.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65463
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13901502
      MA3; MA3 domain
      pfam02854
      Location:9241152
      MIF4G; MIF4G domain
    24. XM_039109655.2XP_038965583.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65459
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13861498
      MA3; MA3 domain
      pfam02854
      Location:9201148
      MIF4G; MIF4G domain
    25. XM_039109657.2XP_038965585.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65452
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13791491
      MA3; MA3 domain
      pfam02854
      Location:9131141
      MIF4G; MIF4G domain
    26. XM_063287461.1XP_063143531.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

      UniProtKB/TrEMBL
      A0A8I6APR0
    27. XM_017593296.3XP_017448785.2  eukaryotic translation initiation factor 4 gamma 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65540
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:14281540
      MA3; MA3 domain
      pfam02854
      Location:9621190
      MIF4G; MIF4G domain
    28. XM_039109654.2XP_038965582.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65502
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13901502
      MA3; MA3 domain
      pfam02854
      Location:9241152
      MIF4G; MIF4G domain
    29. XM_039109656.2XP_038965584.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65495
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13831495
      MA3; MA3 domain
      pfam02854
      Location:9171145
      MIF4G; MIF4G domain
    30. XM_039109658.2XP_038965586.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65491
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13791491
      MA3; MA3 domain
      pfam02854
      Location:9131141
      MIF4G; MIF4G domain
    31. XM_039109660.2XP_038965588.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:70484
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13721484
      MA3; MA3 domain
      pfam02854
      Location:9061134
      MIF4G; MIF4G domain
    32. XM_039109662.2XP_038965590.1  eukaryotic translation initiation factor 4 gamma 3 isoform X35

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:70472
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13471459
      MA3; MA3 domain
      pfam02854
      Location:8811109
      MIF4G; MIF4G domain
    33. XM_039109652.2XP_038965580.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65504
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13921504
      MA3; MA3 domain
      pfam02854
      Location:9261154
      MIF4G; MIF4G domain
    34. XM_039109659.2XP_038965587.1  eukaryotic translation initiation factor 4 gamma 3 isoform X29

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65486
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13741486
      MA3; MA3 domain
      pfam02854
      Location:9081136
      MIF4G; MIF4G domain
    35. XM_039109661.2XP_038965589.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:115488
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13541466
      MA3; MA3 domain
      pfam02854
      Location:8881116
      MIF4G; MIF4G domain
    36. XM_039109664.2XP_038965592.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65468
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13431455
      MA3; MA3 domain
      pfam02854
      Location:8771105
      MIF4G; MIF4G domain
    37. XM_039109666.2XP_038965594.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:69399
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13361448
      MA3; MA3 domain
      pfam02854
      Location:8701098
      MIF4G; MIF4G domain
    38. XM_017593300.3XP_017448789.2  eukaryotic translation initiation factor 4 gamma 3 isoform X23

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (4) summary
      PHA03247
      Location:281519
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13851497
      MA3; MA3 domain
      pfam02854
      Location:9191147
      MIF4G; MIF4G domain
      pfam03154
      Location:68438
      Atrophin-1; Atrophin-1 family
    39. XM_039109663.2XP_038965591.1  eukaryotic translation initiation factor 4 gamma 3 isoform X36

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      pfam02847
      Location:13471459
      MA3; MA3 domain
      pfam02854
      Location:8811109
      MIF4G; MIF4G domain
      pfam03154
      Location:68400
      Atrophin-1; Atrophin-1 family
    40. XM_039109665.2XP_038965593.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      PHA03247
      Location:65465
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13401452
      MA3; MA3 domain
      pfam02854
      Location:8741102
      MIF4G; MIF4G domain
    41. XM_039109667.2XP_038965595.1  eukaryotic translation initiation factor 4 gamma 3 isoform X40

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      pfam02847
      Location:13361448
      MA3; MA3 domain
      pfam02854
      Location:8701098
      MIF4G; MIF4G domain
      pfam03154
      Location:68389
      Atrophin-1; Atrophin-1 family
    42. XM_039109668.2XP_038965596.1  eukaryotic translation initiation factor 4 gamma 3 isoform X41

      UniProtKB/TrEMBL
      A0A8I6APR0
      Conserved Domains (3) summary
      pfam02847
      Location:13291441
      MA3; MA3 domain
      pfam02854
      Location:8631091
      MIF4G; MIF4G domain
      pfam03154
      Location:68382
      Atrophin-1; Atrophin-1 family
    43. XM_039109671.2XP_038965599.1  eukaryotic translation initiation factor 4 gamma 3 isoform X43

      UniProtKB/TrEMBL
      A0A8I6A423
      Related
      ENSRNOP00000080111.1, ENSRNOT00000099490.2
      Conserved Domains (5) summary
      cd11559
      Location:14231555
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:27336
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12211333
      MA3; MA3 domain
      pfam02854
      Location:755983
      MIF4G; MIF4G domain
      cl17013
      Location:15341580
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    44. XM_039109672.2XP_038965600.1  eukaryotic translation initiation factor 4 gamma 3 isoform X44

      UniProtKB/TrEMBL
      A0A8I5ZZ46
      Conserved Domains (3) summary
      PHA03247
      Location:51239
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:11051217
      MA3; MA3 domain
      pfam02854
      Location:639867
      MIF4G; MIF4G domain
    45. XM_039109673.2XP_038965601.1  eukaryotic translation initiation factor 4 gamma 3 isoform X45

      UniProtKB/TrEMBL
      A0A8I5ZZ46
      Conserved Domains (3) summary
      PHA03247
      Location:51238
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:11041216
      MA3; MA3 domain
      pfam02854
      Location:638866
      MIF4G; MIF4G domain
    46. XM_039109674.2XP_038965602.1  eukaryotic translation initiation factor 4 gamma 3 isoform X46

      Conserved Domains (2) summary
      pfam02847
      Location:713825
      MA3; MA3 domain
      pfam02854
      Location:247475
      MIF4G; MIF4G domain
    47. XM_063287468.1XP_063143538.1  eukaryotic translation initiation factor 4 gamma 3 isoform X48

    48. XM_063287467.1XP_063143537.1  eukaryotic translation initiation factor 4 gamma 3 isoform X47

    49. XM_063287469.1XP_063143539.1  eukaryotic translation initiation factor 4 gamma 3 isoform X49

    RNA

    1. XR_010066363.1 RNA Sequence