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    Hand1 heart and neural crest derivatives expressed 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59112, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hand1provided by RGD
    Official Full Name
    heart and neural crest derivatives expressed 1provided by RGD
    Primary source
    RGD:621206
    See related
    EnsemblRapid:ENSRNOG00000002582 AllianceGenome:RGD:621206
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    eHand
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and protein homodimerization activity. Predicted to contribute to transcription cis-regulatory region binding activity. Predicted to be involved in cardiac chamber morphogenesis; in utero embryonic development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including cartilage morphogenesis; circulatory system development; and regulation of DNA-templated transcription. Located in nucleus. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 9.8) and Testes (RPKM 0.9) See more
    Orthologs
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    Genomic context

    See Hand1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42507117..42509684, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42006646..42009213, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43250729..43253296, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480689 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10 Neighboring gene SAP30-like Neighboring gene bolA-like protein 2 Neighboring gene uncharacterized LOC134480691

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC114332

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables bHLH transcription factor binding  
    enables enzyme binding  
    enables identical protein binding  
    enables protein homodimerization activity  
    enables sequence-specific DNA binding  
    contributes_to transcription cis-regulatory region binding  
    enables transcription coregulator binding  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis  
    involved_in biological_process  
    involved_in blastocyst development  
    involved_in cardiac left ventricle formation  
    involved_in cardiac right ventricle formation  
    involved_in cardiac septum morphogenesis  
    acts_upstream_of_or_within cartilage morphogenesis  
    acts_upstream_of_or_within cell differentiation  
    acts_upstream_of_or_within determination of heart left/right asymmetry  
    acts_upstream_of_or_within embryonic heart tube development  
    acts_upstream_of_or_within embryonic heart tube formation  
    involved_in heart development  
    acts_upstream_of_or_within heart development  
    acts_upstream_of_or_within heart looping  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within mesenchyme development  
    acts_upstream_of_or_within mesoderm formation  
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity  
    involved_in negative regulation of DNA-binding transcription factor activity  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in trophectodermal cell differentiation  
    acts_upstream_of_or_within trophoblast giant cell differentiation  
    involved_in trophoblast giant cell differentiation  
    involved_in trophoblast giant cell differentiation  
    acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis  
    involved_in ventricular cardiac muscle tissue morphogenesis  
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    located_in cytoplasm  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    heart- and neural crest derivatives-expressed protein 1
    Names
    extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
    heart and neural crest derivatives expressed transcript 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021592.2NP_067603.1  heart- and neural crest derivatives-expressed protein 1

      See identical proteins and their annotated locations for NP_067603.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097324
      UniProtKB/Swiss-Prot
      P97832, Q4V8L8
      UniProtKB/TrEMBL
      A6HEQ1
      Related
      ENSRNOP00000003486.3, ENSRNOT00000003486.7
      Conserved Domains (1) summary
      smart00353
      Location:103152
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42507117..42509684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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