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    Fnbp1 formin binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192348, updated on 9-Dec-2024

    Summary

    Symbol
    Fnbp1provided by RGD
    Full Name
    formin binding protein 1provided by RGD
    Primary source
    RGD:621350
    See related
    EnsemblRapid:ENSRNOG00000008258 AllianceGenome:RGD:621350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Involved in nervous system development. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human FNBP1 (formin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 85.2), Thymus (RPKM 52.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fnbp1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34706814..34826770, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14309067..14424378, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9865657..9936333, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 78 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene U12 minor spliceosomal RNA Neighboring gene G protein-coupled receptor 107 Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene neuronal calcium sensor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables lipid binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in endocytosis  
    involved_in nervous system development PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in cell cortex  
    located_in clathrin-coated pit  
    located_in cytoplasmic vesicle  
    located_in cytoskeleton  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in lysosome  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    formin-binding protein 1
    Names
    formin-binding protein 1-like
    formin-binding protein 17
    rapostlin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393677.1NP_001380606.1  formin-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q75UE2, Q75UE3, Q75UE4, Q75UE5, Q75UE6, Q8R511
      UniProtKB/TrEMBL
      Z4YNH5
      Related
      ENSRNOP00000092158.2, ENSRNOT00000110957.2
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:406482
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:552608
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
    2. NM_001393678.1NP_001380607.1  formin-binding protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Z4YNH5
      Related
      ENSRNOP00000049838.6, ENSRNOT00000042798.8
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:401477
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:547603
      SH3; Src Homology 3 domain superfamily
    3. NM_001393679.1NP_001380608.1  formin-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:377453
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:523579
      SH3; Src Homology 3 domain superfamily
    4. NM_001393680.1NP_001380609.1  formin-binding protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:372448
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:518574
      SH3; Src Homology 3 domain superfamily
    5. NM_001393681.1NP_001380610.1  formin-binding protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:345421
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:491547
      SH3; Src Homology 3 domain superfamily
    6. NM_001393682.1NP_001380611.1  formin-binding protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:340416
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:486542
      SH3; Src Homology 3 domain superfamily
    7. NM_138914.2NP_620269.1  formin-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_620269.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Z4YNH5
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:406482
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:552608
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34706814..34826770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283065.1XP_063139135.1  formin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AH08, Z4YNH5
    2. XM_063283060.1XP_063139130.1  formin-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      Z4YNH5
    3. XM_063283064.1XP_063139134.1  formin-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      Z4YNH5
    4. XM_063283061.1XP_063139131.1  formin-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GFT9, Z4YNH5
      Related
      ENSRNOP00000088096.1, ENSRNOT00000106082.2
    5. XM_063283070.1XP_063139140.1  formin-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I6A8B9, A0A8I6AD72
      Related
      ENSRNOP00000091155.1, ENSRNOT00000096687.2
    6. XM_063283071.1XP_063139141.1  formin-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A8B9
    7. XM_063283068.1XP_063139138.1  formin-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZUF2, A0A8I6A8B9
      Related
      ENSRNOP00000082158.2, ENSRNOT00000119242.2
    8. XM_063283067.1XP_063139137.1  formin-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      F1LZF2
    9. XM_063283058.1XP_063139128.1  formin-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      Z4YNH5
    10. XM_063283069.1XP_063139139.1  formin-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A8B9
    11. XM_063283066.1XP_063139136.1  formin-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A8B9
    12. XM_063283063.1XP_063139133.1  formin-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      Z4YNH5
    13. XM_063283062.1XP_063139132.1  formin-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      Z4YNH5
    14. XM_063283059.1XP_063139129.1  formin-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Z4YNH5
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