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    Me2 malic enzyme 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Me2provided by RGD
    Official Full Name
    malic enzyme 2provided by RGD
    Primary source
    RGD:1310321
    See related
    EnsemblRapid:ENSRNOG00000015582 AllianceGenome:RGD:1310321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable malate dehydrogenase (decarboxylating) (NAD+) activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process; pyruvate metabolic process; and regulation of NADP metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in mitochondrial matrix. Orthologous to human ME2 (malic enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 144.7), Spleen (RPKM 144.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Me2 in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (69626073..69676218, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (67350833..67400987, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (69737515..69784099, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene EGF-like-domain, multiple 7, pseudogene 1 Neighboring gene elaC ribonuclease Z 1 Neighboring gene uncharacterized LOC134482960 Neighboring gene ribosomal protein L31, pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD binding  
    enables malate dehydrogenase (decarboxylating) (NAD+) activity  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity  
    enables malic enzyme activity  
    enables metal ion binding  
    Process Evidence Code Pubs
    involved_in malate metabolic process  
    involved_in pyruvate metabolic process  
    involved_in pyruvate metabolic process  
    involved_in regulation of NADP metabolic process  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle  
    is_active_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    NAD-dependent malic enzyme, mitochondrial
    Names
    malic enzyme 2, NAD(+)-dependent, mitochondrial
    NP_001100846.2
    XP_006254985.1
    XP_038952708.1
    XP_063133368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107376.2NP_001100846.2  NAD-dependent malic enzyme, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BF522605, CB556640, CB794492, CV796911, EV771591, JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KRC6, D3ZJH9
      Related
      ENSRNOP00000041737.3, ENSRNOT00000049759.6
      Conserved Domains (3) summary
      cd05312
      Location:280558
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:28566
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:89270
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      69626073..69676218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096780.2XP_038952708.1  NAD-dependent malic enzyme, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6KRC6
      Related
      ENSRNOP00000100974.1, ENSRNOT00000163051.1
      Conserved Domains (1) summary
      PLN03129
      Location:35536
      PLN03129; NADP-dependent malic enzyme; Provisional
    2. XM_063277298.1XP_063133368.1  NAD-dependent malic enzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2K502, A6KRC6
      Related
      ENSRNOP00000103470.1, ENSRNOT00000173790.1
    3. XM_006254923.5XP_006254985.1  NAD-dependent malic enzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2K502, A6KRC6
      Conserved Domains (3) summary
      cd05312
      Location:287565
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:35573
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:96277
      malic; Malic enzyme, N-terminal domain
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