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    Kazn kazrin, periplakin interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313672, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kaznprovided by RGD
    Official Full Name
    kazrin, periplakin interacting proteinprovided by RGD
    Primary source
    RGD:1359147
    See related
    EnsemblRapid:ENSRNOG00000014322 AllianceGenome:RGD:1359147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kaz
    Summary
    Predicted to be involved in keratinization. Predicted to be located in several cellular components, including cornified envelope; desmosome; and nuclear speck. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 46.4), Kidney (RPKM 34.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Kazn in Genome Data Viewer
    Location:
    5q36
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159675803..160666084, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (154392793..155381567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160637235..161730513, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene forkhead associated phosphopeptide binding domain 1 Neighboring gene transmembrane protein 51 Neighboring gene uncharacterized LOC134487032 Neighboring gene uncharacterized LOC134487033 Neighboring gene uncharacterized LOC134487030 Neighboring gene uncharacterized LOC134479045 Neighboring gene uncharacterized LOC134479046 Neighboring gene uncharacterized LOC102556543 Neighboring gene uncharacterized LOC120103134 Neighboring gene large ribosomal subunit protein uL5-like Neighboring gene uncharacterized LOC103692503 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene PR/SET domain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC105638

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in keratinization  
    Component Evidence Code Pubs
    located_in cornified envelope  
    located_in cornified envelope  
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in desmosome  
    located_in desmosome  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014070.4NP_001014092.2  kazrin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AAP0, A6ITY6
      Conserved Domains (1) summary
      pfam13863
      Location:129242
      DUF4200; Domain of unknown function (DUF4200)
    2. NM_001415945.1NP_001402874.1  kazrin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q5FWS6
      UniProtKB/TrEMBL
      A0A0H2UHL8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      159675803..160666084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593423.3XP_017448912.1  kazrin isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Related
      ENSRNOP00000019447.8, ENSRNOT00000019447.8
    2. XM_006239310.5XP_006239372.2  kazrin isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Conserved Domains (4) summary
      cd09564
      Location:465534
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:544608
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:630701
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:32262
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. XM_006239311.5XP_006239373.1  kazrin isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Related
      ENSRNOP00000088366.2, ENSRNOT00000118606.2
      Conserved Domains (6) summary
      cd09564
      Location:437506
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:516580
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:602673
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      smart00454
      Location:437504
      SAM; Sterile alpha motif
      pfam05010
      Location:71246
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam13863
      Location:118231
      DUF4200; Domain of unknown function (DUF4200)
    4. XM_039110084.2XP_038966012.1  kazrin isoform X4

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Conserved Domains (4) summary
      cd09564
      Location:349418
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:428492
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:514585
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:25158
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
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