Limk2 LIM domain kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Limk2provided by RGD
Official Full Name: LIM domain kinase 2provided by RGD
Primary source: RGD:62056
See related: EnsemblRapid:ENSRNOG00000019000 AllianceGenome:RGD:62056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Link2; Limk2b
Summary: Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Predicted to be located in centrosome; cis-Golgi network; and mitotic spindle. Predicted to be active in cytoplasm and nucleus. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 42.8), Liver (RPKM 38.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (82384256..82509755, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (78208182..78286106, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (83564048..83641996, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

chronic inhibition of LIMK2 can improve cavernosal veno-occlusive dysfunction and ED by alleviating cavernosal fibrosis via normalizing the LIMK2/Cofilin pathway.
Title: Chronic administration of LIMK2 inhibitors alleviates cavernosal veno-occlusive dysfunction through suppression of cavernosal fibrosis in a rat model of erectile dysfunction after cavernosal nerve injury.
ET-1 may be one of the upstream effectors for programmed neuronal necrosis through abnormal LIMK2 over-expression by ROCK1.
Title: Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity.
Inhibition of LIMK2 expression and rescue of DRP1 function attenuates programmed necrotic neuronal death induced by status epilepticus.
Title: LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission.
Data indicate that LIM motif-containing protein kinases LIMK1 and LIMK2-dependent acin rearrangement is involved in the development of complete Freund's adjuvant (CFA)-induced inflammatory pain.
Title: LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats.
these results indicate that LIMK2d is a third LIMK2 isoform which regulates neurite extension and highlights the possible existence of a kinase independent function of LIMK2.
Title: LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain.

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General gene information

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Markers

RH127162 (e-PCR)
- UniSTS:208633

AI058790 (e-PCR)
- UniSTS:243965

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in astral microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cornea development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in establishment of vesicle localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of vesicle localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of vesicle localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in head development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within head development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	TAS Traceable Author Statement more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LIM domain kinase 2

Names: LIM motif-containing protein kinase 2; LIMK-2

NP_077049.2

EC 2.7.11.1

XP_006251298.1

EC 2.7.11.1

XP_008768501.1

EC 2.7.11.1

XP_063129069.1

EC 2.7.11.1

XP_063129071.1

EC 2.7.11.1

XP_063129072.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024135.3 → NP_077049.2 LIM domain kinase 2

See identical proteins and their annotated locations for NP_077049.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P53670

UniProtKB/TrEMBL

A0A8L2QS45, A6IKA2

Related

ENSRNOP00000026032.3, ENSRNOT00000026032.8

Conserved Domains (5) summary

cd09465
Location:67 → 125

LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)

smart00221
Location:334 → 601

STYKc; Protein kinase; unclassified specificity

cd14222
Location:337 → 608

STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2

pfam00595
Location:152 → 236

PDZ; PDZ domain (Also known as DHR or GLGF)

cl02475
Location:12 → 65

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

82384256..82509755 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251236.5 → XP_006251298.1 LIM domain kinase 2 isoform X2

See identical proteins and their annotated locations for XP_006251298.1

UniProtKB/TrEMBL

A0A8L2QN67, Q5D047

Related

ENSRNOP00000108912.1, ENSRNOT00000123429.1

Conserved Domains (5) summary

cd09465
Location:46 → 104

LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)

smart00221
Location:313 → 580

STYKc; Protein kinase; unclassified specificity

cd14222
Location:316 → 587

STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2

pfam00595
Location:131 → 215

PDZ; PDZ domain (Also known as DHR or GLGF)

cl02475
Location:15 → 44

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_063272999.1 → XP_063129069.1 LIM domain kinase 2 isoform X1

UniProtKB/TrEMBL

A6IKA4

Related

ENSRNOP00000109319.1, ENSRNOT00000163662.1
XM_008770279.4 → XP_008768501.1 LIM domain kinase 2 isoform X3

UniProtKB/TrEMBL

A0A8L2QS45

Conserved Domains (5) summary

cd09465
Location:67 → 125

LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)

smart00221
Location:334 → 591

STYKc; Protein kinase; unclassified specificity

pfam00595
Location:152 → 236

PDZ; PDZ domain (Also known as DHR or GLGF)

cl02475
Location:12 → 65

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

cl21453
Location:337 → 601

PKc_like; Protein Kinases, catalytic domain
XM_063273001.1 → XP_063129071.1 LIM domain kinase 2 isoform X4
XM_063273002.1 → XP_063129072.1 LIM domain kinase 2 isoform X5