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    Ugcg UDP-glucose ceramide glucosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugcgprovided by RGD
    Official Full Name
    UDP-glucose ceramide glucosyltransferaseprovided by RGD
    Primary source
    RGD:621870
    See related
    EnsemblRapid:ENSRNOG00000015644 AllianceGenome:RGD:621870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ceramide glucosyltransferase activity. Predicted to be involved in several processes, including cornified envelope assembly; establishment of skin barrier; and glucosylceramide biosynthetic process. Located in Golgi membrane. Biomarker of hypertension. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 107.6), Spleen (RPKM 95.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ugcg in Genome Data Viewer
    Location:
    5q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (78828006..78860725)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (74032978..74065701)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (76376722..76419564)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene shortage in chiasmata 1 Neighboring gene uncharacterized LOC102550849 Neighboring gene uncharacterized LOC134478985 Neighboring gene uncharacterized LOC102551074 Neighboring gene sushi domain containing 1 Neighboring gene uncharacterized LOC134486940

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2. Silberstein C, et al. Pediatr Res, 2011 May. PMID 21270676
    2. Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning. Takahashi K, et al. J Cereb Blood Flow Metab, 2004 Jun. PMID 15181369
    3. Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study. Wu K, et al. Biochem J, 1999 Jul 15. PMID 10393098, Free PMC Article
    4. Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase. Marks DL, et al. J Biol Chem, 1999 Jan 1. PMID 9867864
    5. Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. Nordström V, et al. PLoS Biol, 2013. PMID 23554574, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2.
      Title: A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2.
    2. Data suggest that during ischemic tolerance, glucosylceramide synthase (GCS) appears to modulate otherwise high levels of brain ceramide.
      Title: Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ceramide glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cornified envelope assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cornified envelope assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucosylceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intestinal lipid absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intestinal lipid absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leptin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein lipidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein lipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ceramide glucosyltransferase
    Names
    GCS
    GLCT-1
    UDP-glucose:N-acylsphingosine D-glucosyltransferase
    UDP-glucose:ceramide glycosyltransferase
    glucosylceramide synthase
    glycosylceramide synthase
    NP_113983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031795.2 → NP_113983.1  ceramide glucosyltransferase

      See identical proteins and their annotated locations for NP_113983.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      O55149, Q9R0E0
      UniProtKB/TrEMBL
      A6KDW2
      Related
      ENSRNOP00000075148.1, ENSRNOT00000088872.3
      Conserved Domains (2) summary
      cd02520
      Location:51 → 280
      Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis
      pfam13641
      Location:51 → 276
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      78828006..78860725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0E0.1 GenPept UniProtKB/Swiss-Prot:Q9R0E0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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