Serbp1 Serpine1 mRNA binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serbp1provided by RGD
Official Full Name: Serpine1 mRNA binding protein 1provided by RGD
Primary source: RGD:619907
See related: EnsemblRapid:ENSRNOG00000005890 AllianceGenome:RGD:619907
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rda288; Pairbp1; Pai-Rbp1
Summary: Predicted to enable several functions, including SUMO binding activity; mRNA 3'-UTR binding activity; and translation elongation factor binding activity. Involved in regulation of apoptotic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human SERBP1 (SERPINE1 mRNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 1203.8), Thymus (RPKM 1137.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (97731200..97748438)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (96401587..96421816)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (98027563..98044717)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies support the concept that the interaction between PAIRBP1-PGRMC1 is an essential component of the mechanism through which progesterone inhibits apoptosis.
Title: Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells.
PAIRBP1 plays an important role in mediating the antiapoptotic action of progesterone in ovarian granulosa and luteal cells.
Title: Expression and function of PAIRBP1 within gonadotropin-primed immature rat ovaries: PAIRBP1 regulation of granulosa and luteal cell viability.
RDA288 in cytoplasm and plasma membrane components of granulosa cells of antral follicles. Present on extracellular surface of plasma membrane. RDA288 plays significant role in mediating progesterone's antiapoptotic action in granulosa cells.
Title: Involvement of an unnamed protein, RDA288, in the mechanism through which progesterone mediates its antiapoptotic action in spontaneously immortalized granulosa cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70271 (e-PCR)
- UniSTS:87695

G43269 (e-PCR)
- UniSTS:94913

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables SUMO binding	IEA Inferred from Electronic Annotation more info
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables SUMO binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation elongation factor binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor binding	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in PML body organization	IEA Inferred from Electronic Annotation more info
involved_in PML body organization	ISO Inferred from Sequence Orthology more info
involved_in PML body organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in ribosome hibernation	IEA Inferred from Electronic Annotation more info
involved_in ribosome hibernation	ISO Inferred from Sequence Orthology more info
involved_in ribosome hibernation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SERPINE1 mRNA-binding protein 1

Names: PAI-1 mRNA-binding protein; PAI1 RNA-binding protein 1; RNA binding protein RDA288; hypothetical RNA binding protein RDA288; plasminogen activator inhibitor 1 RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145086.1 → NP_659554.1 SERPINE1 mRNA-binding protein 1

See identical proteins and their annotated locations for NP_659554.1

Status: PROVISIONAL

Source sequence(s)

BC079337

UniProtKB/TrEMBL

A0A8I6G6Q3, A6KF48

Conserved Domains (2) summary

pfam04774
Location:189 → 297

HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

pfam16174
Location:5 → 152

IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

97731200..97748438

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236616.4 → XP_006236678.1 SERPINE1 mRNA-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_006236678.1

UniProtKB/Swiss-Prot

Q6AXS5, Q8VHU3

UniProtKB/TrEMBL

A0A8I6G6Q3, A6KF47

Related

ENSRNOP00000086511.1, ENSRNOT00000106917.2

Conserved Domains (2) summary

pfam04774
Location:189 → 312

HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

pfam16174
Location:5 → 152

IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
XM_006236617.4 → XP_006236679.1 SERPINE1 mRNA-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6G6Q3

Conserved Domains (2) summary

pfam04774
Location:189 → 306

HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

pfam16174
Location:5 → 152

IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
XM_006236618.4 → XP_006236680.1 SERPINE1 mRNA-binding protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6G6Q3

Conserved Domains (2) summary

pfam04774
Location:189 → 291

HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

pfam16174
Location:5 → 152

IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
XM_039107049.2 → XP_038962977.1 SERPINE1 mRNA-binding protein 1 isoform X4

UniProtKB/TrEMBL

A0A8L2Q518

Related

ENSRNOP00000009503.7, ENSRNOT00000009503.9

Conserved Domains (2) summary

pfam04774
Location:189 → 267

HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

pfam16174
Location:5 → 152

IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal