Adamtsl2 ADAMTS-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamtsl2provided by RGD
Official Full Name: ADAMTS-like 2provided by RGD
Primary source: RGD:1305459
See related: EnsemblRapid:ENSRNOG00000027742 AllianceGenome:RGD:1305459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305459
Summary: Predicted to enable microfibril binding activity. Predicted to act upstream of or within extracellular matrix organization; lobar bronchus epithelium development; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in geleophysic dysplasia 1. Orthologous to human ADAMTSL2 (ADAMTS like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 177.3), Kidney (RPKM 76.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (30795882..30832635)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (10397774..10434557)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (5624473..5654890)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFbeta signalling in cardiac fibroblasts.
Title: The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131264 (e-PCR)
- UniSTS:214547

BE107590 (e-PCR)
- UniSTS:261662

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfibril binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lobar bronchus epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADAMTS-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427090.1 → NP_001414019.1 ADAMTS-like protein 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTK4, D4A4X6

Related

ENSRNOP00000030753.5, ENSRNOT00000036995.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

30795882..30832635

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039106142.2 → XP_038962070.1 ADAMTS-like protein 2 isoform X1

UniProtKB/TrEMBL

A6JTK4, D4A4X6

Conserved Domains (4) summary

smart00209
Location:50 → 106

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:216 → 330

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:922 → 953

PLAC; PLAC (protease and lacunin) domain

pfam19030
Location:804 → 860

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_039106144.2 → XP_038962072.1 ADAMTS-like protein 2 isoform X5

Conserved Domains (3) summary

smart00209
Location:50 → 106

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:216 → 330

ADAM_spacer1; ADAM-TS Spacer 1

pfam19030
Location:574 → 628

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_063283923.1 → XP_063139993.1 ADAMTS-like protein 2 isoform X3
XM_039106143.2 → XP_038962071.1 ADAMTS-like protein 2 isoform X2

UniProtKB/TrEMBL

A6JTK4

Conserved Domains (4) summary

smart00209
Location:50 → 106

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:216 → 330

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:888 → 919

PLAC; PLAC (protease and lacunin) domain

pfam19030
Location:770 → 826

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_063283924.1 → XP_063139994.1 ADAMTS-like protein 2 isoform X4