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    Zkscan2 zinc finger with KRAB and SCAN domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 368120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zkscan2provided by RGD
    Official Full Name
    zinc finger with KRAB and SCAN domains 2provided by RGD
    Primary source
    RGD:1359568
    See related
    EnsemblRapid:ENSRNOG00000024245 AllianceGenome:RGD:1359568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZKSCAN2 (zinc finger with KRAB and SCAN domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 25.2), Testes (RPKM 11.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zkscan2 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (187437095..187459300, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (178006003..178028239, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (193440749..193459755, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483809 Neighboring gene aquaporin 8 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene pyruvate kinase M1/2, pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein with KRAB and SCAN domains 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432375.1 → NP_001419304.1  zinc finger protein with KRAB and SCAN domains 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I905, D3ZXU0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      187437095..187459300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230199.5 → XP_006230261.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

      See identical proteins and their annotated locations for XP_006230261.1

      UniProtKB/TrEMBL
      A6I905, D3ZXU0
      Related
      ENSRNOP00000020281.6, ENSRNOT00000020281.9
      Conserved Domains (9) summary
      smart00431
      Location:42 → 148
      SCAN; leucine rich region
      smart00349
      Location:241 → 282
      KRAB; krueppel associated box
      COG5048
      Location:766 → 915
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:770 → 790
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:768 → 790
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 129
      SCAN; SCAN domain
      pfam13465
      Location:838 → 863
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:334 → 415
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      pfam14510
      Location:466 → 505
      ABC_trans_N; ABC-transporter extracellular N-terminal

    2. XM_039101194.2 → XP_038957122.1  zinc finger protein with KRAB and SCAN domains 2 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:538 → 687
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:542 → 562
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13837
      Location:262 → 343
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02605
      Location:42 → 148
      SCAN; SCAN oligomerization domain

    3. XM_001079250.8 → XP_001079250.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

      Conserved Domains (9) summary
      smart00431
      Location:42 → 148
      SCAN; leucine rich region
      smart00349
      Location:241 → 282
      KRAB; krueppel associated box
      COG5048
      Location:766 → 915
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:770 → 790
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:768 → 790
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 129
      SCAN; SCAN domain
      pfam13465
      Location:838 → 863
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:334 → 415
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      pfam14510
      Location:466 → 505
      ABC_trans_N; ABC-transporter extracellular N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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