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    Cep83 centrosomal protein 83 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366872, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Cep83provided by RGD
    Official Full Name
    centrosomal protein 83provided by RGD
    Primary source
    RGD:1359593
    See related
    EnsemblRapid:ENSRNOG00000007859 AllianceGenome:RGD:1359593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc41; RGD1359593
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly; establishment of centrosome localization; and vesicle docking. Predicted to act upstream of or within protein localization to centrosome. Predicted to be part of ciliary transition fiber. Predicted to be active in Golgi apparatus; centriole; and centrosome. Human ortholog(s) of this gene implicated in nephronophthisis 18. Orthologous to human CEP83 (centrosomal protein 83). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 257.2), Brain (RPKM 180.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep83 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (31167198..31276513)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (29280358..29389574)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35739553..35847618)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit f, pseudogene 3 Neighboring gene centrosomal protein 83, opposite strand Neighboring gene uncharacterized LOC120093560 Neighboring gene plexin C1 Neighboring gene uncharacterized LOC134479861 Neighboring gene uncharacterized LOC120093559

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CCDC41 is required for ciliary vesicle docking to the mother centriole. Joo K, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23530209, Free PMC Article
    2. Centriole distal appendages promote membrane docking, leading to cilia initiation. Tanos BE, et al. Genes Dev, 2013 Jan 15. PMID 23348840, Free PMC Article
    3. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Ye X, et al. Proc Natl Acad Sci U S A, 2014 Feb 11. PMID 24469809, Free PMC Article
    4. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ciliary transition fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 83 kDa
    Names
    coiled-coil domain containing 41
    coiled-coil domain-containing protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014266.2 → NP_001014288.1  centrosomal protein of 83 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q66H89
      UniProtKB/TrEMBL
      A6IG23
      Conserved Domains (1) summary
      COG1196
      Location:39 → 622
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      31167198..31276513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264031.1 → XP_063120101.1  centrosomal protein of 83 kDa isoform X2

      UniProtKB/Swiss-Prot
      Q66H89
      UniProtKB/TrEMBL
      A6IG23

    2. XM_063264027.1 → XP_063120097.1  centrosomal protein of 83 kDa isoform X1

    3. XM_063264030.1 → XP_063120100.1  centrosomal protein of 83 kDa isoform X1

    4. XM_063264032.1 → XP_063120102.1  centrosomal protein of 83 kDa isoform X3

    5. XM_063264036.1 → XP_063120106.1  centrosomal protein of 83 kDa isoform X8

    6. XM_008765317.4 → XP_008763539.1  centrosomal protein of 83 kDa isoform X4

      Related
      ENSRNOP00000031786.5, ENSRNOT00000034639.6
      Conserved Domains (2) summary
      COG1196
      Location:39 → 622
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:157 → 234
      DUF342; Protein of unknown function (DUF342)

    7. XM_063264035.1 → XP_063120105.1  centrosomal protein of 83 kDa isoform X6

    8. XM_039079678.2 → XP_038935606.1  centrosomal protein of 83 kDa isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:39 → 267
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:172 → 507
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_063264037.1 → XP_063120107.1  centrosomal protein of 83 kDa isoform X9

    10. XM_063264034.1 → XP_063120104.1  centrosomal protein of 83 kDa isoform X5

    11. XM_063264042.1 → XP_063120112.1  centrosomal protein of 83 kDa isoform X14

    12. XM_063264041.1 → XP_063120111.1  centrosomal protein of 83 kDa isoform X13

    13. XM_063264038.1 → XP_063120108.1  centrosomal protein of 83 kDa isoform X10

    14. XM_063264039.1 → XP_063120109.1  centrosomal protein of 83 kDa isoform X11

    15. XM_063264043.1 → XP_063120113.1  centrosomal protein of 83 kDa isoform X14

    16. XM_063264033.1 → XP_063120103.1  centrosomal protein of 83 kDa isoform X4

    17. XM_063264026.1 → XP_063120096.1  centrosomal protein of 83 kDa isoform X1

    18. XM_017595016.3 → XP_017450505.1  centrosomal protein of 83 kDa isoform X2

      UniProtKB/Swiss-Prot
      Q66H89
      UniProtKB/TrEMBL
      A6IG23
      Conserved Domains (1) summary
      COG1196
      Location:39 → 622
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    19. XM_063264028.1 → XP_063120098.1  centrosomal protein of 83 kDa isoform X1

    20. XM_063264040.1 → XP_063120110.1  centrosomal protein of 83 kDa isoform X12

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H89.1 GenPept UniProtKB/Swiss-Prot:Q66H89

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