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    Carm1 coactivator-associated arginine methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363026, updated on 4-Jan-2025

    Summary

    Official Symbol
    Carm1provided by RGD
    Official Full Name
    coactivator-associated arginine methyltransferase 1provided by RGD
    Primary source
    RGD:1305879
    See related
    EnsemblRapid:ENSRNOG00000031129 AllianceGenome:RGD:1305879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prmt4
    Summary
    Predicted to enable several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in negative regulation of dendrite development; positive regulation of cell population proliferation; and response to cAMP. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nuclear replication fork. Biomarker of asthma; hepatocellular adenoma; and hepatocellular carcinoma. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 111.1), Heart (RPKM 110.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Carm1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28373370..28418056)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20097262..20141950)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22577723..22622555)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dynamin 2 Neighboring gene uncharacterized LOC134480146 Neighboring gene similar to human chromosome 19 open reading frame 38 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X, pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene Yip1 domain family, member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 Neighboring gene uncharacterized LOC134480145

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 33
    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables histone H2AQ104 methyltransferase activity  
    enables histone H3K37 methyltransferase activity  
    enables histone H3K56 methyltransferase activity  
    enables histone H3R17 methyltransferase activity  
    enables histone H3R17 methyltransferase activity  
    enables histone H3R2 methyltransferase activity  
    enables histone H3R2 methyltransferase activity  
    enables histone H3R2 methyltransferase activity  
    enables histone H3R26 methyltransferase activity  
    enables histone H3R26 methyltransferase activity  
    enables histone H3R8 methyltransferase activity  
    enables histone H4K12 methyltransferase activity  
    enables histone H4R3 methyltransferase activity  
    enables histone arginine N-methyltransferase activity  
    enables histone methyltransferase activity  
    enables histone methyltransferase activity  
    enables lysine-acetylated histone binding  
    enables lysine-acetylated histone binding  
    enables nuclear receptor coactivator activity  
    enables nuclear receptor coactivator activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein methyltransferase activity  
    enables protein-arginine N-methyltransferase activity  
    enables protein-arginine N-methyltransferase activity  
    enables protein-arginine N-methyltransferase activity  
    enables protein-arginine omega-N asymmetric methyltransferase activity  
    enables protein-arginine omega-N asymmetric methyltransferase activity  
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    Items 1 - 25 of 33
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in RNA splicing  
    acts_upstream_of cell population proliferation  
    involved_in chromatin organization  
    involved_in chromatin remodeling  
    acts_upstream_of_or_within endochondral bone morphogenesis  
    acts_upstream_of_or_within estrogen receptor signaling pathway  
    involved_in mRNA processing  
    involved_in methylation  
    involved_in negative regulation of dendrite development PubMed 
    involved_in nuclear receptor-mediated steroid hormone signaling pathway  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of epithelial cell apoptotic process  
    involved_in positive regulation of fat cell differentiation  
    involved_in positive regulation of fat cell differentiation  
    involved_in positive regulation of transcription by RNA polymerase I  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within protein localization to chromatin  
    acts_upstream_of_or_within protein methylation  
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of growth plate cartilage chondrocyte proliferation  
    involved_in regulation of intracellular estrogen receptor signaling pathway  
    involved_in regulation of intracellular estrogen receptor signaling pathway  
    involved_in replication fork reversal  
    involved_in replication fork reversal  
    involved_in response to cAMP PubMed 
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    located_in chromosome  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in nuclear replication fork  
    is_active_in nuclear replication fork  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    histone-arginine methyltransferase CARM1
    Names
    protein arginine N-methyltransferase 4
    NP_001025212.1
    NP_001029260.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030041.4NP_001025212.1  histone-arginine methyltransferase CARM1 isoform a

      See identical proteins and their annotated locations for NP_001025212.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A068FP44, A6JNT0
      Related
      ENSRNOP00000042739.4, ENSRNOT00000048245.8
      Conserved Domains (2) summary
      cd02440
      Location:189284
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam11531
      Location:35139
      CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
    2. NM_001034088.3NP_001029260.1  histone-arginine methyltransferase CARM1 isoform b

      See identical proteins and their annotated locations for NP_001029260.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A068FP44
      Related
      ENSRNOP00000049428.5, ENSRNOT00000041577.6
      Conserved Domains (2) summary
      cd02440
      Location:189284
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam11531
      Location:35139
      CARM1; Coactivator-associated arginine methyltransferase 1 N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28373370..28418056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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