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    PCBP2 poly(rC) binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 5094, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PCBP2provided by HGNC
    Official Full Name
    poly(rC) binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:8648
    See related
    Ensembl:ENSG00000197111 MIM:601210; AllianceGenome:HGNC:8648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPE2; HNRNPE2; hnRNP-E2
    Summary
    The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
    Expression
    Ubiquitous expression in kidney (RPKM 155.8), thyroid (RPKM 127.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PCBP2 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53452102..53481162)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53418139..53447209)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53845886..53874946)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53834490-53835255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4510 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4513 Neighboring gene proline rich 13 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53876139-53876652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4514 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene Sharpr-MPRA regulatory region 1043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6423 Neighboring gene ATF7-NPFF readthrough Neighboring gene TARBP2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration. Davidson YS, et al. Acta Neuropathol Commun, 2017 Jun 30. PMID 28666471, Free PMC Article
    2. High expression of PCBP2 is associated with progression and poor prognosis in patients with glioblastoma. Luo K, et al. Biomed Pharmacother, 2017 Oct. PMID 28787701
    3. HnRNP E2 is downregulated in human oral cancer cells and the overexpression of hnRNP E2 induces apoptosis. Roychoudhury P, et al. Mol Carcinog, 2007 Mar. PMID 17219427
    4. Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution. Fenn S, et al. Nucleic Acids Res, 2007. PMID 17426136, Free PMC Article
    5. X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. Du Z, et al. RNA, 2007 Jul. PMID 17526645, Free PMC Article

    See all (328) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA.
      Title: HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA.
    2. Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac.
      Title: Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac.
    3. UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
      Title: UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
    4. Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.
      Title: Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.
    5. Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase.
      Title: Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase.
    6. Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
      Title: Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
    7. The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
      Title: The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
    8. MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
      Title: MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
    9. PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.
      Title: PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.
    10. Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA.
      Title: Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA.
    Submit: New GeneRIF Correction See all GeneRIFs (78)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) E2 PubMed
    Tat tat Poly(rC) binding protein 2 (PCBP2) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110998

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lncRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables promoter-enhancer loop anchoring activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cGAS/STING signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in viral RNA genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(rC)-binding protein 2
    Names
    alpha-CP2
    epididymis secretory sperm binding protein
    heterogeneous nuclear ribonucleoprotein E2
    heterogenous nuclear ribonucleoprotein E2
    hnRNP E2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098620.3 → NP_001092090.1  poly(rC)-binding protein 2 isoform c

      See identical proteins and their annotated locations for NP_001092090.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, BF509278
      Consensus CDS
      CCDS44903.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000352228.5, ENST00000359282.9
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:250 → 325
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    2. NM_001128911.2 → NP_001122383.1  poly(rC)-binding protein 2 isoform d

      See identical proteins and their annotated locations for NP_001122383.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is one amino acid shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, BF509278, X78136
      Consensus CDS
      CCDS44901.1
      UniProtKB/Swiss-Prot
      A8K7X6, B4DXP5, F8VYL7, G3V0E8, I6L8F9, Q15366, Q32Q82, Q59HD4, Q68Y55, Q6IPF4, Q6PKG5
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000408949.2, ENST00000439930.7
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:284 → 359
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    3. NM_001128912.2 → NP_001122384.1  poly(rC)-binding protein 2 isoform e

      See identical proteins and their annotated locations for NP_001122384.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses two alternate in-frame splice sites compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is five amino acids shorter compared to isoform a.
      Source sequence(s)
      AB188306, AB208825, AC023509, AK130583, BF509278
      Consensus CDS
      CCDS55830.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000448927.2, ENST00000552296.6
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:280 → 355
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    4. NM_001128913.2 → NP_001122385.1  poly(rC)-binding protein 2 isoform f

      See identical proteins and their annotated locations for NP_001122385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, BC107688, BF509278
      Consensus CDS
      CCDS44902.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000394116.1, ENST00000447282.5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:254 → 329
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    5. NM_001128914.2 → NP_001122386.1  poly(rC)-binding protein 2 isoform g

      See identical proteins and their annotated locations for NP_001122386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, AK225357, BF509278
      Consensus CDS
      CCDS44904.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000390304.1, ENST00000437231.5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:237 → 312
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    6. NM_005016.6 → NP_005007.2  poly(rC)-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_005007.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB188306, AC023509, AK130583, BC035420, BF509278
      Consensus CDS
      CCDS44900.1
      UniProtKB/TrEMBL
      A0A384N6B9, H3BRU6
      Related
      ENSP00000352438.5, ENST00000359462.9
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:285 → 360
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    7. NM_031989.5 → NP_114366.1  poly(rC)-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_114366.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, AK292141, BF509278
      Consensus CDS
      CCDS8859.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000448762.2, ENST00000546463.6
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53452102..53481162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      53418139..53447209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15366.1 GenPept UniProtKB/Swiss-Prot:Q15366

    Gene LinkOut

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