DNMT3A DNA methyltransferase 3 alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: DNMT3Aprovided by HGNC
Official Full Name: DNA methyltransferase 3 alphaprovided by HGNC
Primary source: HGNC:HGNC:2978
See related: Ensembl:ENSG00000119772 MIM:602769; AllianceGenome:HGNC:2978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TBRS; HESJAS; DNMT3A2; M.HsaIIIA
Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Expression: Ubiquitous expression in placenta (RPKM 5.8), ovary (RPKM 3.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.3

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (25227874..25342590, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (25263222..25377928, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (25450743..25565459, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aortic disease and cardiomyopathy in patients with a novel DNMT3A gene variant causing Tatton-Brown-Rahman syndrome.
Title: Aortic disease and cardiomyopathy in patients with a novel DNMT3A gene variant causing Tatton-Brown-Rahman syndrome.
Adenosine kinase inhibits beta-cell proliferation by upregulating DNA methyltransferase 3A expression.
Title: Adenosine kinase inhibits β-cell proliferation by upregulating DNA methyltransferase 3A expression.
KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
Title: KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
Effect of DNMT3A R882H Hot Spot Mutations on DDX43 Promoter Methylation in Acute Myeloid Leukemia.
Title: Effect of DNMT3A R882H Hot Spot Mutations on DDX43 Promoter Methylation in Acute Myeloid Leukemia.
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Title: Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
[Research progress on DNMT3A gene expression in Acute myeloid leukemia].
Title: [Research progress on DNMT3A gene expression in Acute myeloid leukemia].
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss.
Title: Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss.
[Relationship between DTA Mutations and Thromboembolism in Patients with Myeloproliferative Neoplasms].
Title: [Relationship between DTA Mutations and Thromboembolism in Patients with Myeloproliferative Neoplasms].
Loss of Dnmt3a increases self-renewal and resistance to pegIFN-alpha in JAK2-V617F-positive myeloproliferative neoplasms.
Title: Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2-V617F-positive myeloproliferative neoplasms.
DNA methyltransferase 3A induces the occurrence of oral submucous fibrosis by promoting the methylation of the von Hippel-Lindau.
Title: DNA methyltransferase 3A induces the occurrence of oral submucous fibrosis by promoting the methylation of the von Hippel-Lindau.

Submit: New GeneRIF Correction See all GeneRIFs (508)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Acute myeloid leukemia MedGen: C0023467 OMIM: 601626 GeneReviews: CEBPA-Associated Familial Acute Myeloid Leukemia (AML), ETV6 Thrombocytopenia and Predisposition to Leukemia, RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies, DDX41-Associated Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia	not available
Heyn-Sproul-Jackson syndrome MedGen: C5231475 OMIM: 618724 GeneReviews: Not available	not available
Tatton-Brown-Rahman overgrowth syndrome MedGen: C4014545 OMIM: 615879 GeneReviews: Tatton-Brown-Rahman Syndrome	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2024-09-25) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2024-09-25) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates DNMT1, DNMT3A, and DNMT3B both at the mRNA and protein levels in primary tumors	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26721-26722:1034781098:3 (e-PCR)
- UniSTS:269059

D2S2119 (e-PCR)
- UniSTS:154127

RH45375 (e-PCR)
- UniSTS:58754

D2S1959E (e-PCR)
- UniSTS:153731

D2S2703 (e-PCR)
- UniSTS:82863

D2S144 (e-PCR)
- UniSTS:68025

A007B06 (e-PCR)
- UniSTS:61928

RH130466 (e-PCR)
- UniSTS:213750

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA (cytosine-5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA (cytosine-5-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates	IEA Inferred from Electronic Annotation more info
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates	IEA Inferred from Electronic Annotation more info
enables DNA binding	EXP Inferred from Experiment more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	TAS Traceable Author Statement more info	PubMed
enables unmethylated CpG binding	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autosome genomic imprinting	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to bisphenol A	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in response to lead ion	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to vitamin A	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in XY body	IEA Inferred from Electronic Annotation more info
part_of catalytic complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: DNA (cytosine-5)-methyltransferase 3A

Names: DNA (cytosine-5-)-methyltransferase 3 alpha; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2; cysteine methyltransferase DNMT3A

NP_001307821.1

EC 2.1.1.37

NP_001307822.1

EC 2.1.1.37

NP_001362748.1

EC 2.1.1.37

NP_072046.2

EC 2.1.1.37

NP_715640.2

EC 2.1.1.37

NP_783328.1

EC 2.1.1.37

NP_783329.1

EC 2.1.1.37

XP_005264232.1

EC 2.1.1.37

XP_011530964.1

EC 2.1.1.37

XP_011530966.1

EC 2.1.1.37

XP_011530968.1

EC 2.1.1.37

XP_011530969.1

EC 2.1.1.37

XP_016859015.1

EC 2.1.1.37

XP_016859016.1

EC 2.1.1.37

XP_047299548.1

EC 2.1.1.37

XP_047299549.1

EC 2.1.1.37

XP_047299550.1

EC 2.1.1.37

XP_047299552.1

EC 2.1.1.37

XP_047299553.1

EC 2.1.1.37

XP_047299554.1

EC 2.1.1.37

XP_047299555.1

EC 2.1.1.37

XP_054196875.1

EC 2.1.1.37

XP_054196876.1

EC 2.1.1.37

XP_054196877.1

EC 2.1.1.37

XP_054196878.1

EC 2.1.1.37

XP_054196879.1

EC 2.1.1.37

XP_054196880.1

EC 2.1.1.37

XP_054196881.1

EC 2.1.1.37

XP_054196882.1

EC 2.1.1.37

XP_054196883.1

EC 2.1.1.37

XP_054196884.1

EC 2.1.1.37

XP_054196885.1

EC 2.1.1.37

XP_054196886.1

EC 2.1.1.37

XP_054196887.1

EC 2.1.1.37

XP_054196888.1

EC 2.1.1.37

XP_054196889.1

EC 2.1.1.37

XP_054196890.1

EC 2.1.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029465.2 RefSeqGene

Range

5001..114630

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_459

mRNA and Protein(s)

NM_001320892.2 → NP_001307821.1 DNA (cytosine-5)-methyltransferase 3A isoform c

Status: REVIEWED

Source sequence(s)

AC012074, AL543971, BC032392, BC043617

Consensus CDS

CCDS46232.1

UniProtKB/Swiss-Prot

Q9Y6K1

Conserved Domains (1) summary

PTZ00449
Location:4 → 82

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
NM_001320893.1 → NP_001307822.1 DNA (cytosine-5)-methyltransferase 3A isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses a downstream promoter compared to variants 1, 3, 4 and 7.

Source sequence(s)

AB208833, AC012074, AF480163, AI376254

UniProtKB/Swiss-Prot

Q9Y6K1

UniProtKB/TrEMBL

Q59HC6

Conserved Domains (4) summary

cd05835
Location:138 → 224

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:480 → 643

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

PRK07003
Location:30 → 130

PRK07003; DNA polymerase III subunit gamma/tau

cd11729
Location:335 → 462

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
NM_001375819.1 → NP_001362748.1 DNA (cytosine-5)-methyltransferase 3A isoform e

Status: REVIEWED

Source sequence(s)

AC012074

Consensus CDS

CCDS92718.1

UniProtKB/TrEMBL

A0A0C4DG02

Related

ENSP00000384237.1, ENST00000402667.1

Conserved Domains (3) summary

cd05835
Location:67 → 153

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

cd11729
Location:264 → 391

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:409 → 572

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
NM_022552.5 → NP_072046.2 DNA (cytosine-5)-methyltransferase 3A isoform a

Status: REVIEWED

Source sequence(s)

AC012074

Consensus CDS

CCDS33157.1

UniProtKB/Swiss-Prot

E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1

UniProtKB/TrEMBL

Q59HC6

Related

ENSP00000324375.5, ENST00000321117.10

Conserved Domains (4) summary

cd05835
Location:290 → 376

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:632 → 795

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:487 → 614

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl25756
Location:11 → 156

BASP1; Brain acid soluble protein 1 (BASP1 protein)
NM_153759.3 → NP_715640.2 DNA (cytosine-5)-methyltransferase 3A isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a downstream promoter compared to variants 1, 3, 4, and 7.

Source sequence(s)

AF331856, AF480163, AI376254, BM470515

Consensus CDS

CCDS1718.2

UniProtKB/Swiss-Prot

Q9Y6K1

Related

ENSP00000370122.4, ENST00000380746.8

Conserved Domains (3) summary

cd05835
Location:101 → 187

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:443 → 606

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:298 → 425

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
NM_175629.2 → NP_783328.1 DNA (cytosine-5)-methyltransferase 3A isoform a

Status: REVIEWED

Source sequence(s)

AF331856, AI376254, BC032392

Consensus CDS

CCDS33157.1

UniProtKB/Swiss-Prot

E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1

UniProtKB/TrEMBL

Q59HC6

Related

ENSP00000264709.3, ENST00000264709.7

Conserved Domains (4) summary

cd05835
Location:290 → 376

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:632 → 795

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:487 → 614

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl25756
Location:11 → 156

BASP1; Brain acid soluble protein 1 (BASP1 protein)
NM_175630.1 → NP_783329.1 DNA (cytosine-5)-methyltransferase 3A isoform c

Status: REVIEWED

Source sequence(s)

BC032392

Consensus CDS

CCDS46232.1

UniProtKB/Swiss-Prot

Q9Y6K1

Related

ENSP00000384852.3, ENST00000406659.3

RNA

NR_135490.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AB208833, AC012074, AI376254

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

25227874..25342590 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005264175.6 → XP_005264232.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1

UniProtKB/TrEMBL

Q59HC6

Conserved Domains (4) summary

cd05835
Location:290 → 376

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:632 → 795

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:487 → 614

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl25756
Location:11 → 156

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_017003526.2 → XP_016859015.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1

UniProtKB/TrEMBL

Q59HC6

Conserved Domains (4) summary

cd05835
Location:290 → 376

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:632 → 795

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:487 → 614

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl25756
Location:11 → 156

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_011532662.3 → XP_011530964.1 DNA (cytosine-5)-methyltransferase 3A isoform X2

UniProtKB/TrEMBL

Q59HC6

Conserved Domains (3) summary

cd05835
Location:241 → 327

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:583 → 746

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:438 → 565

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_047443592.1 → XP_047299548.1 DNA (cytosine-5)-methyltransferase 3A isoform X3
XM_047443594.1 → XP_047299550.1 DNA (cytosine-5)-methyltransferase 3A isoform X7
XM_011532667.4 → XP_011530969.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02

Conserved Domains (3) summary

cd05835
Location:67 → 153

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

cd11729
Location:264 → 391

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:409 → 572

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_017003527.2 → XP_016859016.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02

Conserved Domains (3) summary

cd05835
Location:67 → 153

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

cd11729
Location:264 → 391

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:409 → 572

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_047443598.1 → XP_047299554.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02
XM_011532666.3 → XP_011530968.1 DNA (cytosine-5)-methyltransferase 3A isoform X6

Conserved Domains (3) summary

cd05835
Location:114 → 200

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:456 → 619

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:311 → 438

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_047443596.1 → XP_047299552.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02
XM_047443597.1 → XP_047299553.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02
XM_047443593.1 → XP_047299549.1 DNA (cytosine-5)-methyltransferase 3A isoform X4

UniProtKB/TrEMBL

Q59HC6
XM_011532664.3 → XP_011530966.1 DNA (cytosine-5)-methyltransferase 3A isoform X5

UniProtKB/TrEMBL

F8WE91, Q59HC6

Related

ENSP00000370132.3, ENST00000380756.7

Conserved Domains (3) summary

cd05835
Location:290 → 376

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:632 → 781

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:487 → 614

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_047443599.1 → XP_047299555.1 DNA (cytosine-5)-methyltransferase 3A isoform X9

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

25263222..25377928 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054340901.1 → XP_054196876.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1

UniProtKB/TrEMBL

Q59HC6
XM_054340900.1 → XP_054196875.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1

UniProtKB/TrEMBL

Q59HC6
XM_054340902.1 → XP_054196877.1 DNA (cytosine-5)-methyltransferase 3A isoform X2

UniProtKB/TrEMBL

Q59HC6
XM_054340903.1 → XP_054196878.1 DNA (cytosine-5)-methyltransferase 3A isoform X3
XM_054340909.1 → XP_054196884.1 DNA (cytosine-5)-methyltransferase 3A isoform X7
XM_054340910.1 → XP_054196885.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02
XM_054340913.1 → XP_054196888.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02
XM_054340908.1 → XP_054196883.1 DNA (cytosine-5)-methyltransferase 3A isoform X6
XM_054340911.1 → XP_054196886.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02
XM_054340912.1 → XP_054196887.1 DNA (cytosine-5)-methyltransferase 3A isoform X8

UniProtKB/TrEMBL

A0A0C4DG02
XM_054340907.1 → XP_054196882.1 DNA (cytosine-5)-methyltransferase 3A isoform X11
XM_054340906.1 → XP_054196881.1 DNA (cytosine-5)-methyltransferase 3A isoform X10
XM_054340904.1 → XP_054196879.1 DNA (cytosine-5)-methyltransferase 3A isoform X4

UniProtKB/TrEMBL

Q59HC6
XM_054340915.1 → XP_054196890.1 DNA (cytosine-5)-methyltransferase 3A isoform X5

UniProtKB/TrEMBL

F8WE91, Q59HC6
XM_054340905.1 → XP_054196880.1 DNA (cytosine-5)-methyltransferase 3A isoform X5

UniProtKB/TrEMBL

F8WE91, Q59HC6
XM_054340914.1 → XP_054196889.1 DNA (cytosine-5)-methyltransferase 3A isoform X9