Cdc42bpg CDC42 binding protein kinase gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc42bpgprovided by RGD
Official Full Name: CDC42 binding protein kinase gammaprovided by RGD
Primary source: RGD:1307260
See related: EnsemblRapid:ENSRNOG00000027456 AllianceGenome:RGD:1307260
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307260
Summary: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization and protein phosphorylation. Predicted to be located in cell leading edge; centriolar satellite; and cytosol. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human CDC42BPG (CDC42 binding protein kinase gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 154.7), Kidney (RPKM 110.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213037603..213057764)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203608339..203628502)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221673334..221693518)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW107720 (e-PCR)
- UniSTS:209415

stSG635729 (e-PCR)
- UniSTS:460899

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase MRCK gamma

Names: CDC42 binding protein kinase gamma (DMPK-like)

NP_001123485.1

EC 2.7.11.1

XP_006230813.1

EC 2.7.11.1

XP_038964401.1

EC 2.7.11.1

XP_038964412.1

EC 2.7.11.1

XP_038964415.1

EC 2.7.11.1

XP_038964426.1

EC 2.7.11.1

XP_063142946.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130013.1 → NP_001123485.1 serine/threonine-protein kinase MRCK gamma

See identical proteins and their annotated locations for NP_001123485.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A6HZG0

Conserved Domains (6) summary

pfam08826
Location:744 → 799

DMPK_coil; DMPK coiled coil domain like

smart00220
Location:71 → 337

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01243
Location:938 → 1070

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

pfam00130
Location:879 → 927

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00780
Location:1097 → 1360

CNH; CNH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213037603..213057764

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108498.2 → XP_038964426.1 serine/threonine-protein kinase MRCK gamma isoform X5

Conserved Domains (5) summary

cd01243
Location:846 → 978

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:1 → 301

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

TIGR02168
Location:352 → 711

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00780
Location:1005 → 1268

CNH; CNH domain

cd20866
Location:787 → 838

C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
XM_063286876.1 → XP_063142946.1 serine/threonine-protein kinase MRCK gamma isoform X6
XM_039108487.2 → XP_038964415.1 serine/threonine-protein kinase MRCK gamma isoform X3

Conserved Domains (5) summary

cd01243
Location:943 → 1075

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

TIGR02168
Location:450 → 809

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00780
Location:1102 → 1365

CNH; CNH domain

cd20866
Location:884 → 935

C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
XM_039108473.1 → XP_038964401.1 serine/threonine-protein kinase MRCK gamma isoform X1

Conserved Domains (5) summary

cd01243
Location:944 → 1076

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

TIGR02168
Location:450 → 809

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00780
Location:1103 → 1366

CNH; CNH domain

cd20866
Location:885 → 936

C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
XM_039108484.1 → XP_038964412.1 serine/threonine-protein kinase MRCK gamma isoform X2

Related

ENSRNOP00000029466.7, ENSRNOT00000038016.7

Conserved Domains (5) summary

cd01243
Location:944 → 1076

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

TIGR02168
Location:450 → 809

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00780
Location:1103 → 1366

CNH; CNH domain

cd20866
Location:885 → 936

C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
XM_006230751.5 → XP_006230813.1 serine/threonine-protein kinase MRCK gamma isoform X4

UniProtKB/TrEMBL

D3Z837

Related

ENSRNOP00000108240.1, ENSRNOT00000135588.1

Conserved Domains (6) summary

pfam08826
Location:744 → 799

DMPK_coil; DMPK coiled coil domain like

smart00220
Location:71 → 337

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01243
Location:938 → 1070

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

pfam00130
Location:879 → 927

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00780
Location:1097 → 1360

CNH; CNH domain