Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chchd4provided by RGD
Official Full Name: coiled-coil-helix-coiled-coil-helix domain containing 4provided by RGD
Primary source: RGD:1310746
See related: EnsemblRapid:ENSRNOG00000022466 AllianceGenome:RGD:1310746
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein-disulfide reductase activity. Predicted to be involved in several processes, including peptidyl-cysteine oxidation; protein folding; and protein import into mitochondrial intermembrane space. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; mitochondrial DNA repair; and regulation of protein export from nucleus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 130.4), Muscle (RPKM 129.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (125525428..125534562, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (123968264..123977398, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (123108924..123118186, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension.
Title: Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 'de novo' post-translational protein folding	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' post-translational protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial DNA repair	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial disulfide relay system	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-cysteine oxidation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-cysteine oxidation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation by protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by protein folding	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitochondrial intermembrane space import and assembly protein 40

Names: coiled-coil-helix-coiled-coil-helix domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.