Sae1 SUMO1 activating enzyme subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sae1provided by RGD
Official Full Name: SUMO1 activating enzyme subunit 1provided by RGD
Primary source: RGD:1306098
See related: EnsemblRapid:ENSRNOG00000015128 AllianceGenome:RGD:1306098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Uble1a
Summary: Predicted to enable several functions, including ATP-dependent protein binding activity; SUMO activating enzyme activity; and protein heterodimerization activity. Predicted to be involved in positive regulation of protein sumoylation; positive regulation of protein targeting to mitochondrion; and protein sumoylation. Predicted to be located in nucleoplasm. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 213.9), Heart (RPKM 187.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86159114..86215089, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77030961..77086937, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78277524..78333281, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb04e11.y1 (e-PCR)
- UniSTS:189862

BE116482 (e-PCR)
- UniSTS:248492

BE117351 (e-PCR)
- UniSTS:261806

RH129134 (e-PCR)
- UniSTS:212442

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables SUMO activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to SUMO activating enzyme activity	ISO Inferred from Sequence Orthology more info
contributes_to SUMO activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables small protein activating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein modification by small protein conjugation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SUMO activating enzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SUMO activating enzyme complex	ISO Inferred from Sequence Orthology more info
part_of SUMO activating enzyme complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SUMO-activating enzyme subunit 1

Names: ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1-activating enzyme E1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012063.1 → NP_001012063.1 SUMO-activating enzyme subunit 1

See identical proteins and their annotated locations for NP_001012063.1

Status: PROVISIONAL

Source sequence(s)

BC079411

UniProtKB/Swiss-Prot

Q6AXQ0

UniProtKB/TrEMBL

A0A8I5ZL60, A6J8A6

Related

ENSRNOP00000020402.4, ENSRNOT00000020402.8

Conserved Domains (1) summary

cd01492
Location:19 → 344

Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...