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    C1h10orf90 similar to human chromosome 10 open reading frame 90 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100302465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C1h10orf90provided by RGD
    Official Full Name
    similar to human chromosome 10 open reading frame 90provided by RGD
    Primary source
    RGD:2311471
    See related
    EnsemblRapid:ENSRNOG00000027542 AllianceGenome:RGD:2311471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone deacetylase binding activity; microtubule binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein stabilization; regulation of cell cycle process; and response to ionizing radiation. Predicted to be located in actin cytoskeleton; cytoplasm; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human C10orf90 (chromosome 10 open reading frame 90). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 75.5) and Brain (RPKM 16.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See C1h10orf90 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (198489686..198723260, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (189059744..189293353, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (206324763..206417143, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene uncharacterized LOC134483951 Neighboring gene neuromedin U receptor 1, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene dedicator of cyto-kinesis 1 Neighboring gene inhibitory synaptic factor 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FATS is a transcriptional target of p53 and associated with antitumor activity. Zhang X, et al. Mol Cancer, 2010 Sep 16. PMID 20843368, Free PMC Article
    2. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. Knorz VJ, et al. Mol Biol Cell, 2010 Nov 1. PMID 20844083, Free PMC Article
    3. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Li Z, et al. Oncogene, 2010 May 6. PMID 20154723
    4. FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. Yan S, et al. Oncogene, 2014 Nov 20. PMID 24240685
    5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC187524

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    (E2-independent) E3 ubiquitin-conjugating enzyme FATS
    Names
    centrosomal protein C10orf90 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163214.3 → NP_001156686.2  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K7C9, B3DMA4
      Related
      ENSRNOP00000106148.1, ENSRNOT00000168561.1
      Conserved Domains (1) summary
      pfam15309
      Location:569 → 697
      ALMS_motif; ALMS motif

    2. NM_001419533.1 → NP_001406462.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HX50, F6WET6
      Related
      ENSRNOP00000031960.7, ENSRNOT00000038122.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      198489686..198723260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107617.1 → XP_038963545.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X6

      UniProtKB/TrEMBL
      M0R7T5
      Conserved Domains (2) summary
      pfam15309
      Location:496 → 623
      ALMS_motif; ALMS motif
      pfam17730
      Location:82 → 491
      Centro_C10orf90; Centrosomal C10orf90

    2. XM_039106695.1 → XP_038962623.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X1

      UniProtKB/TrEMBL
      M0R7T5
      Related
      ENSRNOP00000078061.2, ENSRNOT00000116082.2
      Conserved Domains (2) summary
      pfam15309
      Location:591 → 718
      ALMS_motif; ALMS motif
      pfam17730
      Location:82 → 586
      Centro_C10orf90; Centrosomal C10orf90

    3. XM_063287197.1 → XP_063143267.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X8

      UniProtKB/TrEMBL
      M0R7T5

    4. XM_063286673.1 → XP_063142743.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKF8, M0R7T5
      Related
      ENSRNOP00000100483.1, ENSRNOT00000146575.1

    5. XM_063286459.1 → XP_063142529.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X3

      UniProtKB/TrEMBL
      A6HX49, M0R7T5

    6. XM_063287020.1 → XP_063143090.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X7

      UniProtKB/TrEMBL
      B3DMA4

    7. XM_063285879.1 → XP_063141949.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X2

      UniProtKB/TrEMBL
      B3DMA4
      Related
      ENSRNOP00000065518.3, ENSRNOT00000073836.4

    8. XM_039106880.2 → XP_038962808.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X3

      UniProtKB/TrEMBL
      A6HX49, M0R7T5
      Conserved Domains (2) summary
      pfam15309
      Location:550 → 677
      ALMS_motif; ALMS motif
      pfam17730
      Location:41 → 545
      Centro_C10orf90; Centrosomal C10orf90

    9. XM_039107221.2 → XP_038963149.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X5

      UniProtKB/TrEMBL
      M0R7T5
      Related
      ENSRNOP00000074153.3, ENSRNOT00000091863.3
      Conserved Domains (2) summary
      pfam15309
      Location:514 → 641
      ALMS_motif; ALMS motif
      pfam17730
      Location:5 → 509
      Centro_C10orf90; Centrosomal C10orf90
    Nucleotide Protein Strain
    Heading Accession and Version

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