Ltc4s leukotriene C4 synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ltc4sprovided by RGD
Official Full Name: leukotriene C4 synthaseprovided by RGD
Primary source: RGD:620677
See related: EnsemblRapid:ENSRNOG00000003244 AllianceGenome:RGD:620677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables glutathione binding activity and leukotriene-C4 synthase activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to vitamin A; and leukotriene biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and nuclear outer membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Biomarker of glomerulonephritis and peripheral nervous system disease. Orthologous to human LTC4S (leukotriene C4 synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 8.5), Heart (RPKM 8.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (35060002..35066466, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (34560476..34562790, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (35736486..35743088, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LTC4S and Orai3 altered Akt signaling to promote VSMC migration and neointima formation.
Title: Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.
5-LOX is involved in global cerebral ischemic damage in rats
Title: [Expression of 5-lipoxygenase in hippocampal CA1 neuronal damage following global cerebral ischemia in rats].
Liver LTC4S was up-regulated in rat model of fulminant hepatic failure.
Title: Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model.
In the myeloid cells, but not in the epithelial cells, we observed that the leukotriene C(4) synthase promoter activity was stimulated by 12-O-tetradecanoylphorbol-13-acetate and all-trans-retinoic acid.
Title: Leukotriene C4 synthase promoter driven expression of GFP reveals cell specificity.
molecular cloning; elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid
Title: cDNA cloning and expression of rat leukotriene C(4) synthase: elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid.
BRET data showed that hydrophobic regions 1 and 3 each allowed oligomerization to occur. These regions most likely form transmembrane helices, suggesting that homo-oligomerization of LTC4S is due to helix-helix interactions in the membrane.
Title: Identification of regions of leukotriene C4 synthase which direct the enzyme to its nuclear envelope localization.
LTC4S may be involved in acute systemic inflammatory responses such as fever and tachycardia.
Title: Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis.
Induction in basophilic leukemia cells with retinoice acid and actinomycin D; suppressed with methylprednisolone.
Title: Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone.
hepatic ischemia reperfusion injury up-regulated the mRNA and protein expressions of LTC4S in hepatocytes and sinusoidal endothelial cells and enhanced the activities of the LTC4 synthesis enzymes
Title: Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables glutathione binding	IDA Inferred from Direct Assay more info	PubMed
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables leukotriene-C4 synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene-C4 synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene-C4 synthase activity	IEA Inferred from Electronic Annotation more info
enables leukotriene-C4 synthase activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in leukotriene biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in leukotriene biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within leukotriene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leukotriene C4 synthase

Names: LTC4 synthase; glutathione S-transferase LTC4; leukotriene-C(4) synthase

XP_006246281.1

EC 4.4.1.20

XP_038940948.1

EC 4.4.1.20

XP_063124336.1

EC 4.4.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053639.3 → NP_446091.3 leukotriene C4 synthase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

G3V6E6, Q925U2

UniProtKB/TrEMBL

A0A8L2Q1E0

Related

ENSRNOP00000004359.2, ENSRNOT00000004359.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

35060002..35066466 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268266.1 → XP_063124336.1 leukotriene C4 synthase isoform X1

Related

ENSRNOP00000087343.1, ENSRNOT00000110795.2
XM_039085020.2 → XP_038940948.1 leukotriene C4 synthase isoform X3

UniProtKB/TrEMBL

A6HE07

Conserved Domains (1) summary

pfam01124
Location:8 → 100

MAPEG; MAPEG family
XM_006246219.3 → XP_006246281.1 leukotriene C4 synthase isoform X2

UniProtKB/TrEMBL

A0A8L2Q1E0

Related

ENSRNOP00000107331.1, ENSRNOT00000173148.1

Conserved Domains (1) summary

pfam01124
Location:41 → 125

MAPEG; MAPEG family