Snap47 synaptosome associated protein 47 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snap47provided by RGD
Official Full Name: synaptosome associated protein 47provided by RGD
Primary source: RGD:735194
See related: EnsemblRapid:ENSRNOG00000022472 AllianceGenome:RGD:735194
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SNAP-47; RGD735194
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane; synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Predicted to act upstream of or within long-term synaptic potentiation. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density; and presynaptic active zone. Orthologous to human SNAP47 (synaptosome associated protein 47). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 159.3), Muscle (RPKM 123.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44692430..44733986, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44192886..44234435, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45757196..45798734, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNAP-47, a novel Qbc-SNARE with ubiquitous expression
Title: Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport in synapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	ISO Inferred from Sequence Orthology more info
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptosomal-associated protein 47

Names: synaptosomal-associated 47 kDa protein; synaptosomal-associated protein, 47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199389.1 → NP_955421.1 synaptosomal-associated protein 47

See identical proteins and their annotated locations for NP_955421.1

Status: PROVISIONAL

Source sequence(s)

BC062056

UniProtKB/Swiss-Prot

Q6P6S0

Related

ENSRNOP00000076626.1, ENSRNOT00000119360.2

Conserved Domains (3) summary

cd15854
Location:359 → 417

SNARE_SNAP47C; C-terminal SNARE motif of SNAP47

cd15888
Location:106 → 170

SNARE_SNAP47N; N-terminal SNARE motif of SNAP47

cl17171
Location:12 → 98

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

44692430..44733986 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246488.5 → XP_006246550.1 synaptosomal-associated protein 47 isoform X1

See identical proteins and their annotated locations for XP_006246550.1

UniProtKB/Swiss-Prot

Q6P6S0

Conserved Domains (3) summary

cd15854
Location:359 → 417

SNARE_SNAP47C; C-terminal SNARE motif of SNAP47

cd15888
Location:106 → 170

SNARE_SNAP47N; N-terminal SNARE motif of SNAP47

cl17171
Location:12 → 98

PH-like; Pleckstrin homology-like domain