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    Zp3r zona pellucida 3 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289010, updated on 9-Dec-2024

    Summary

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    Symbol
    Zp3rprovided by RGD
    Full Name
    zona pellucida 3 receptorprovided by RGD
    Primary source
    RGD:727846
    See related
    EnsemblRapid:ENSRNOG00000025862 AllianceGenome:RGD:727846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    sp56
    Summary
    Involved in binding activity of sperm to zona pellucida. Located in acrosomal matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 79.0) See more
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    Genomic context

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    See Zp3r in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (44572283..44617101, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42019998..42064836, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47286375..47331213, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene CD55 molecule (Cromer blood group) Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene complement component 4 binding protein, alpha Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of rat sp56, the homologue of mouse sperm ZP3 receptor-sp56. He XB, et al. Cell Res, 2003 Apr. PMID 12737520
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94417

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zona pellucida sperm-binding protein 3 receptor
    Names
    sperm fertilization protein 56
    zona pellucida sperm-binding protein 3 receptor-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270844.1 → NP_001257773.1  zona pellucida sperm-binding protein 3 receptor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice site at the 5' end of the first coding exon compared to variant 1. The resulting isoform (2) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      BC079287, JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q7TSY3, Q7TSY4
      UniProtKB/TrEMBL
      F7EUY5
      Related
      ENSRNOP00000048027.4, ENSRNOT00000049915.6
      Conserved Domains (4) summary
      cd00033
      Location:409 → 464
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:305 → 366
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:40 → 294
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:178 → 233
      Sushi; Sushi repeat (SCR repeat)

    2. NM_001270845.1 → NP_001257774.1  zona pellucida sperm-binding protein 3 receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001257774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      BC079287, JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q7TSY3, Q7TSY4
      UniProtKB/TrEMBL
      Q6AXW5
      Conserved Domains (4) summary
      cd00033
      Location:388 → 443
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:284 → 345
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:19 → 273
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:157 → 212
      Sushi; Sushi repeat (SCR repeat)

    3. NM_182815.2 → NP_877967.2  zona pellucida sperm-binding protein 3 receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_877967.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC079287, JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q7TSY3, Q7TSY4
      UniProtKB/TrEMBL
      A6IBY6, G3V902
      Conserved Domains (4) summary
      cd00033
      Location:157 → 218
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:349 → 410
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:19 → 277
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:222 → 277
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      44572283..44617101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598691.3 → XP_017454180.1  zona pellucida sperm-binding protein 3 receptor isoform X2

      UniProtKB/Swiss-Prot
      Q7TSY3, Q7TSY4

    2. XM_006249713.5 → XP_006249775.1  zona pellucida sperm-binding protein 3 receptor isoform X1

      See identical proteins and their annotated locations for XP_006249775.1

      UniProtKB/Swiss-Prot
      Q7TSY3, Q7TSY4
      Related
      ENSRNOP00000031964.5, ENSRNOT00000035577.8
      Conserved Domains (4) summary
      cd00033
      Location:178 → 239
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:370 → 431
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:40 → 298
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:243 → 298
      Sushi; Sushi repeat (SCR repeat)

    3. XM_063272065.1 → XP_063128135.1  zona pellucida sperm-binding protein 3 receptor isoform X4

      UniProtKB/Swiss-Prot
      Q7TSY3, Q7TSY4

    4. XM_063272064.1 → XP_063128134.1  zona pellucida sperm-binding protein 3 receptor isoform X3

      UniProtKB/Swiss-Prot
      Q7TSY3, Q7TSY4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSY4.1 GenPept UniProtKB/Swiss-Prot:Q7TSY4

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